Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.
Citation: XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.

Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC

  • Received Date: 2007-02-09
  • Objective: To determine residual di-paraxylylene in parylene film coated rubber closure by HPLC. Methods: Parylene film coated rubber closures were extracted with acetone,which then evaporated and transferred with ethanol to volumetric flask,the val- idation of the method was tested and the test condition was confirmed.The chromatography condition was with HP Hyporsil ODS C18 column(4.0 mm×125 mm,5μm),mobile phase was methanol:water(87:13),flow speed was 1.0 mL/min,detection wavelength was 224 nm. Results: The peak area of di-paraxylylene correlated well to injection mass in range of 0.1~2.0 mg/L.The stability (RSD)was 0.6% in 24 h.The recoveries were 101.14%(RSD=0.8%,n=9).The limit of detection was 4.0×10-10g.Conclu- sion:The method was fast and accurate,and suitable for determining the content of residual di-paraxylylene in parylene film coated rubber closure.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2143) PDF downloads(38) Cited by()

Related
Proportional views

Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC

Abstract: Objective: To determine residual di-paraxylylene in parylene film coated rubber closure by HPLC. Methods: Parylene film coated rubber closures were extracted with acetone,which then evaporated and transferred with ethanol to volumetric flask,the val- idation of the method was tested and the test condition was confirmed.The chromatography condition was with HP Hyporsil ODS C18 column(4.0 mm×125 mm,5μm),mobile phase was methanol:water(87:13),flow speed was 1.0 mL/min,detection wavelength was 224 nm. Results: The peak area of di-paraxylylene correlated well to injection mass in range of 0.1~2.0 mg/L.The stability (RSD)was 0.6% in 24 h.The recoveries were 101.14%(RSD=0.8%,n=9).The limit of detection was 4.0×10-10g.Conclu- sion:The method was fast and accurate,and suitable for determining the content of residual di-paraxylylene in parylene film coated rubber closure.

XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.
Citation: XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return