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XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.
Citation: XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.

Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC

  • Received Date: 2007-02-09
  • Objective: To determine residual di-paraxylylene in parylene film coated rubber closure by HPLC. Methods: Parylene film coated rubber closures were extracted with acetone,which then evaporated and transferred with ethanol to volumetric flask,the val- idation of the method was tested and the test condition was confirmed.The chromatography condition was with HP Hyporsil ODS C18 column(4.0 mm×125 mm,5μm),mobile phase was methanol:water(87:13),flow speed was 1.0 mL/min,detection wavelength was 224 nm. Results: The peak area of di-paraxylylene correlated well to injection mass in range of 0.1~2.0 mg/L.The stability (RSD)was 0.6% in 24 h.The recoveries were 101.14%(RSD=0.8%,n=9).The limit of detection was 4.0×10-10g.Conclu- sion:The method was fast and accurate,and suitable for determining the content of residual di-paraxylylene in parylene film coated rubber closure.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC

Abstract: Objective: To determine residual di-paraxylylene in parylene film coated rubber closure by HPLC. Methods: Parylene film coated rubber closures were extracted with acetone,which then evaporated and transferred with ethanol to volumetric flask,the val- idation of the method was tested and the test condition was confirmed.The chromatography condition was with HP Hyporsil ODS C18 column(4.0 mm×125 mm,5μm),mobile phase was methanol:water(87:13),flow speed was 1.0 mL/min,detection wavelength was 224 nm. Results: The peak area of di-paraxylylene correlated well to injection mass in range of 0.1~2.0 mg/L.The stability (RSD)was 0.6% in 24 h.The recoveries were 101.14%(RSD=0.8%,n=9).The limit of detection was 4.0×10-10g.Conclu- sion:The method was fast and accurate,and suitable for determining the content of residual di-paraxylylene in parylene film coated rubber closure.

XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.
Citation: XU Jun, JIANG Jun, LU Ying. Determination of residual di-paraxylylene in Parylene film coated rubber closure by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 235-237.

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