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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (1): 23-27,50

SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
Citation: SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
shu

Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

  • 1.

    Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China

  • 2.

    Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, Shanghai 200433, China

  • 3.

    Department of Natural Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2007-08-28
  • Rev Recd Date: 2007-09-03
  • Objective: To investigate the effects of Dehydrocavidine (YHL-DC) on carbon tetrachloride (CCl4) induced acute liver injury in mice. Methods: The mice were pre-treatment with YHL-DC prior to the administration of CCl4 and post-treatment with YHL-DC after the administration of CCl4, and the changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in these mice were examined respectively. Histopathology changes of liver were also observed under both light and electron microscope. Results: Pre-treatment and post-treatment with YHL-DC significantly prevented increase in serum enzymatic activities of ALT, AST and TBIL in a dose-dependent manner. Hepatocyte degeneration and necrosis, infiltration of inflammatory cells and destruction of hepatocyte ultrastructure appeared in carbon tetrachloride induced acute injured liver in mice, while extenuations were observed in both pre-and post-treatment groups administered with YHL-DC. Conclusion: The results suggest that YHL-DC has a potent hepatoprotective action on CCl4 induced acute liver injury in mice.
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Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

  • 1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
  • 2. Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, Shanghai 200433, China
  • 3. Department of Natural Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2007-08-28
  • Rev Recd Date: 2007-09-03

Abstract: Objective: To investigate the effects of Dehydrocavidine (YHL-DC) on carbon tetrachloride (CCl4) induced acute liver injury in mice. Methods: The mice were pre-treatment with YHL-DC prior to the administration of CCl4 and post-treatment with YHL-DC after the administration of CCl4, and the changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in these mice were examined respectively. Histopathology changes of liver were also observed under both light and electron microscope. Results: Pre-treatment and post-treatment with YHL-DC significantly prevented increase in serum enzymatic activities of ALT, AST and TBIL in a dose-dependent manner. Hepatocyte degeneration and necrosis, infiltration of inflammatory cells and destruction of hepatocyte ultrastructure appeared in carbon tetrachloride induced acute injured liver in mice, while extenuations were observed in both pre-and post-treatment groups administered with YHL-DC. Conclusion: The results suggest that YHL-DC has a potent hepatoprotective action on CCl4 induced acute liver injury in mice.

SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
Citation: SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
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