Experimental studies on hypoglycemic effect of KetangteⅡ

Key words: 
• streptozotocin /
• hypoglycemic /
• insulin

Abstract: Objective: To investigate the hypoglycemic effects and its mechanism of KTTⅡ on streptozotocin(STZ)-induced diabetic mice. Methods: Diabetic model mice is established by injecting 150 mg/kg of STZ.These mice were divided into five groups randomly: model group,glibenclamide group(50 mg/kg·d,ig),high dose group of KTTⅡ(25 g/kg·d,ig),middle dose group of KTT(12.5 g/kg·d,ig) and low dose group of KTTⅡ(6.25 g/kg·d,ig),while the control and model group were administrated with the same volume of physiological saline for 15 days.During the experiment,the fasting blood glucose(FBG),insulin,creatinine(Cr),uric acid(UA),albumen(Alb) were measured at different time. Results: KTT Ⅱcould reduce the blood glucose concentration significantly in STZ-induced diabetic mice which was positively correlated with dosage-effect and time-effect.KTTⅡ could raise insulin level,and decrease Cr and UA levels in serum(P<0.01),increase Alb level in serum(P<0.05). Conclusion: The results suggested that KTTⅡ could decrease blood glucose,improve insulin level in STZ-induced diabetic mice,indicating that KTTⅡ may have a potential value for the treatment of DM and DM complications.The mechanism of reducing blood glucose is probably associated with promoting insulin secretion.