Study on stability of valproic acid and carbamazepine concentrations in serum samples
- Received Date: 2007-03-06
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Key words:
- valproic acid /
- carbamazepine /
- serum drug concentration
Abstract: Objective: To investigate the effects on serum drug concentrations of valproic acid and carbamazepine with different storage requirements of serum sample. Methods: Methods The serum samples from epileptic patients were stored at normal temperature(23 ℃±2 ℃)for 7 days and 14 days or in refrigerator(5 ℃±1 ℃) for 7 days.Then these samples were determined by FPIA and the results were compared with the new ones. Results: Compared with the new samples,the samples which were stored for 7 or 14 days were no significant differences. Conclusion: Serum samples of valproic acid and carbamazepine can be stored stably at normal temperature for 14 days.
Citation: | ZHOU Liang, WANG Ming-Mei, MA Jian-Li. Study on stability of valproic acid and carbamazepine concentrations in serum samples[J]. Journal of Pharmaceutical Practice and Service, 2008, (2): 145-146,153. |