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Volume 26 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (3): 178-181

JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: ZHANG Jun, SUN Qing-yan, XU Jian-ming, XUE Yun-yun, ZENG Juan, HUANG Xiao-jin, WU Qiu-ye. 3 D-QSAR Study of a Series of 6-[4-Substituted-piperazinyl) phenyl]-4,5-Dihydro-3(2H)-Pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 178-181.
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3 D-QSAR Study of a Series of 6-[4-Substituted-piperazinyl) phenyl]-4,5-Dihydro-3(2H)-Pyridazinones

  • 1.

    School of Pharmacy,Second Military Medicial University,Shanghai,200433,China

  • 2.

    School of Pharmacy,East China University of Science & Technology,Shanghai,200237,China

  • 3.

    Department of Medicament,No.85 Hospital of PLA,Shanghai,200052,China

  • Received Date: 2007-11-05
  • Three dimensional structure-activity relationship(3D-QSAR) has been studied on a series of 6-[4-Substituted-piperazinyl) phenyl]-4,5-Dihydro-3(2H)-Pyridazinones by using.Using comparative molecular field analysis(CoMFA).The resulting CoMFA model had a cross validated coeffiecient q2 of 0.663 respectively,which showed a strong predictive ability.The 3D contour maps of CoMFA provided a smooth and interpretable explanation of the structure-antiplatelet aggregation activity relationship for the compounds.The analysis of the 3D contour plots permitted interesting conclusions about the effects of different substituent groups at the position of the N atom on the terminal of piperazidine group on the antiplatelet aggregation activity,which will guide the design of novel antiplatelet aggregation compounds with relatively high activity.
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-040Highcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 83.1 %FULLTEXT: 83.1 %META: 15.7 %META: 15.7 %PDF: 1.3 %PDF: 1.3 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 19.9 %其他: 19.9 %其他: 0.2 %其他: 0.2 %China: 0.6 %China: 0.6 %United States: 0.2 %United States: 0.2 %[]: 0.2 %[]: 0.2 %上海: 0.6 %上海: 0.6 %北京: 9.3 %北京: 9.3 %杭州: 0.2 %杭州: 0.2 %梧州: 0.2 %梧州: 0.2 %海得拉巴: 0.8 %海得拉巴: 0.8 %芒廷维尤: 18.4 %芒廷维尤: 18.4 %西宁: 49.2 %西宁: 49.2 %其他其他ChinaUnited States[]上海北京杭州梧州海得拉巴芒廷维尤西宁Highcharts.com
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3 D-QSAR Study of a Series of 6-[4-Substituted-piperazinyl) phenyl]-4,5-Dihydro-3(2H)-Pyridazinones

  • 1. School of Pharmacy,Second Military Medicial University,Shanghai,200433,China
  • 2. School of Pharmacy,East China University of Science & Technology,Shanghai,200237,China
  • 3. Department of Medicament,No.85 Hospital of PLA,Shanghai,200052,China
  • Received Date: 2007-11-05

Abstract: Three dimensional structure-activity relationship(3D-QSAR) has been studied on a series of 6-[4-Substituted-piperazinyl) phenyl]-4,5-Dihydro-3(2H)-Pyridazinones by using.Using comparative molecular field analysis(CoMFA).The resulting CoMFA model had a cross validated coeffiecient q2 of 0.663 respectively,which showed a strong predictive ability.The 3D contour maps of CoMFA provided a smooth and interpretable explanation of the structure-antiplatelet aggregation activity relationship for the compounds.The analysis of the 3D contour plots permitted interesting conclusions about the effects of different substituent groups at the position of the N atom on the terminal of piperazidine group on the antiplatelet aggregation activity,which will guide the design of novel antiplatelet aggregation compounds with relatively high activity.

JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: ZHANG Jun, SUN Qing-yan, XU Jian-ming, XUE Yun-yun, ZENG Juan, HUANG Xiao-jin, WU Qiu-ye. 3 D-QSAR Study of a Series of 6-[4-Substituted-piperazinyl) phenyl]-4,5-Dihydro-3(2H)-Pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 178-181.
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