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GU Wei-feng, PIAO Shu-juan, ZHANG Chun. Determination of salicylic acid and tetracation hydrochloride in Compound onychomycosis cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 217-219.
Citation: GU Wei-feng, PIAO Shu-juan, ZHANG Chun. Determination of salicylic acid and tetracation hydrochloride in Compound onychomycosis cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 217-219.

Determination of salicylic acid and tetracation hydrochloride in Compound onychomycosis cream by HPLC

  • Received Date: 2007-07-05
  • Objective: To establish a HPLC method for the determination of salicylic acid and tetracation hydrochloride in compound onychomycosis cream. Methods: Agilent-C18(4.6 mm×150 mm,5 μm) column was used with a mobile phase of methanol-water-phosphoric(50500.04) and a flow rate of l.0 mL/min,at the detection wavelength of 313 nm. Results: This method showed good linear relation(r= 0.999 9) in the range of 82.00~410.00 μg/mL for salicylic acid,and 5.00~25.00 μg/mL for tetracation hydrochloride.The average recoveries were 99.80% and 99.75%,with the relative standard deviation of 1.68% and 1.36%,respectively. Conclusion: The method is simple,quick,accurate and suitable for the quality control of compound onychomycosis cream.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of salicylic acid and tetracation hydrochloride in Compound onychomycosis cream by HPLC

Abstract: Objective: To establish a HPLC method for the determination of salicylic acid and tetracation hydrochloride in compound onychomycosis cream. Methods: Agilent-C18(4.6 mm×150 mm,5 μm) column was used with a mobile phase of methanol-water-phosphoric(50500.04) and a flow rate of l.0 mL/min,at the detection wavelength of 313 nm. Results: This method showed good linear relation(r= 0.999 9) in the range of 82.00~410.00 μg/mL for salicylic acid,and 5.00~25.00 μg/mL for tetracation hydrochloride.The average recoveries were 99.80% and 99.75%,with the relative standard deviation of 1.68% and 1.36%,respectively. Conclusion: The method is simple,quick,accurate and suitable for the quality control of compound onychomycosis cream.

GU Wei-feng, PIAO Shu-juan, ZHANG Chun. Determination of salicylic acid and tetracation hydrochloride in Compound onychomycosis cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 217-219.
Citation: GU Wei-feng, PIAO Shu-juan, ZHANG Chun. Determination of salicylic acid and tetracation hydrochloride in Compound onychomycosis cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 217-219.

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