Preparation of aspirin intergastric floating tablet with carrier of oyster shell powder and sodium carboxymethyl cellulose

Key words: 
• oyster shell powder /
• aspirin /
• floating tablets /
• release

Abstract: Objective: To prepare aspirin floating tablets which used the oyster shell powder and sodium carboxymethyl cellulose (CMC) as compound drug carrier,end investigate its release characteristics and floating property in vitro. Methods: The drug release was detected in vitro by UV spectrometry.According to the cumulative release curve,the mathematical models for the release process of each group of aspirin floating tablets were studied.And how the dosage of the oyster shell powder and sodium carboxymethyl cellulose influenced the release process was investigated. Results: The second prescription had satisfactory floating property and ideal release process in vitro,and its process accorded with zero-order kinetics process of the medicine characteristic.The simulation equation was Q =0.080 4 t+0.146 2 with the R (correlation coefficient)=0.998 7. Conclusion:: Aspirin floating tablets were prepared and the drug release equation and release pattern was established.