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Volume 26 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (4): 272-273,298

YU Da-hai, MAO Shi-long. Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 272-273,298.
Citation: YU Da-hai, MAO Shi-long. Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 272-273,298.
shu

Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits

  • 1.

    The 404th Hospital of PLA,Weihai 264200,China

  • 2.

    Department of Pharmacy,Xuhui District Central Hospital,Shanghai 200031,China

  • Received Date: 2007-05-14
  • Objective: To study the effects of acanthopanax senticosus saponins (ASS)on platelet,blood coagulation and blood vis- cosity in rabbits. Methods: Platelet aggregation,APTT (activated partial thromboplastin time),PT (prothrombin time),TT (Thrombin time),blood viscosity,plasma viscosity and hematocrit were measured by mutifunctional intellectual blood coagulation analyzer and self erasure rotary viscometer after rabbit was fed with ASS. Results: ASS significantly inhibited platelet aggregation induced by ADP, and ASS can decrease the blood viscosity significantly.But it had no effect on APT1",PT and I3". Conclusion:: ASS possessed the abili- ty of improving blood viscosity and inhibiting thrombosis.This effect was due to its action on decreasing erythrocyte aggregation and blood stickiness.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits

  • 1. The 404th Hospital of PLA,Weihai 264200,China
  • 2. Department of Pharmacy,Xuhui District Central Hospital,Shanghai 200031,China
  • Received Date: 2007-05-14

Abstract: Objective: To study the effects of acanthopanax senticosus saponins (ASS)on platelet,blood coagulation and blood vis- cosity in rabbits. Methods: Platelet aggregation,APTT (activated partial thromboplastin time),PT (prothrombin time),TT (Thrombin time),blood viscosity,plasma viscosity and hematocrit were measured by mutifunctional intellectual blood coagulation analyzer and self erasure rotary viscometer after rabbit was fed with ASS. Results: ASS significantly inhibited platelet aggregation induced by ADP, and ASS can decrease the blood viscosity significantly.But it had no effect on APT1",PT and I3". Conclusion:: ASS possessed the abili- ty of improving blood viscosity and inhibiting thrombosis.This effect was due to its action on decreasing erythrocyte aggregation and blood stickiness.

YU Da-hai, MAO Shi-long. Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 272-273,298.
Citation: YU Da-hai, MAO Shi-long. Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 272-273,298.
shu

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