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Volume 26 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (4): 274-277

ZHANG Jing, WANG Wei, GENG Xin-hui. The preparation and purification of silybin meglumine[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 274-277.
Citation: ZHANG Jing, WANG Wei, GENG Xin-hui. The preparation and purification of silybin meglumine[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 274-277.
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The preparation and purification of silybin meglumine

  • 1.

    Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China

  • 2.

    Chuzhou Institute for Food and Drug,Anhui,Chuzhou,239000,China

  • Received Date: 2008-04-28
  • Objective: To study the preparation and purification of silybin meglumine. Methods: IThe procedure of the preparation included two steps:first,the crude silybin was recrgstallized with absolute alcohol,and activated carbon which was used to adsorb im- purity simultaneously.Then,the purificatory product and meglumine were used to preparation silybin meglumine. Results: The content of silybin meglumine in preparation products was higher than 96% detected by ultraviolet spectrometer and 80% detected by high per- formance liquid chromatography (HPLC).The mass rate is approximately 72.1%. Conclusion:: This experiment proved that the pro- duction process of silybin meglumine was stable,each step of operating conditions was easy to control.The product quality was reliable and suitable for industrial production.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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The preparation and purification of silybin meglumine

  • 1. Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
  • 2. Chuzhou Institute for Food and Drug,Anhui,Chuzhou,239000,China
  • Received Date: 2008-04-28

Abstract: Objective: To study the preparation and purification of silybin meglumine. Methods: IThe procedure of the preparation included two steps:first,the crude silybin was recrgstallized with absolute alcohol,and activated carbon which was used to adsorb im- purity simultaneously.Then,the purificatory product and meglumine were used to preparation silybin meglumine. Results: The content of silybin meglumine in preparation products was higher than 96% detected by ultraviolet spectrometer and 80% detected by high per- formance liquid chromatography (HPLC).The mass rate is approximately 72.1%. Conclusion:: This experiment proved that the pro- duction process of silybin meglumine was stable,each step of operating conditions was easy to control.The product quality was reliable and suitable for industrial production.

ZHANG Jing, WANG Wei, GENG Xin-hui. The preparation and purification of silybin meglumine[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 274-277.
Citation: ZHANG Jing, WANG Wei, GENG Xin-hui. The preparation and purification of silybin meglumine[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 274-277.
shu

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