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Volume 26 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (4): 278-281

SUN Liang, HUANG Xiao-jin, FAN Song-jie, YU Shi-chong, WU Qiu-ye. Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 278-281.
Citation: SUN Liang, HUANG Xiao-jin, FAN Song-jie, YU Shi-chong, WU Qiu-ye. Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 278-281.
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Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones

  • 1.

    Department of Organic Chemistry,College of Pharmacy,Second Military Medical University,Shanghai 200433,China

  • 2.

    The No.85th Hospital of PLA,Shanghai 200052,China

  • Received Date: 2008-04-14
  • Objective: To study the antiplatelet aggregative aclivity nf 6-（4-substituted acetamido-phenyl）-4,5-dihydro-3（2H）-py- ridazinones with different heterocylic groups. Methods: Ten target compounds were designed and synthesized.All of them were con- firmed by 1H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggre- gative activity to a certain extent.Compound （5）,（9） and （10） were better than MCI-154 in vitro. Conclusion:: The stereospecifie blockade and hydrophilieity of different heterocylic groups impacted the antiplatelet aggregative activity.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones

  • 1. Department of Organic Chemistry,College of Pharmacy,Second Military Medical University,Shanghai 200433,China
  • 2. The No.85th Hospital of PLA,Shanghai 200052,China
  • Received Date: 2008-04-14

Abstract: Objective: To study the antiplatelet aggregative aclivity nf 6-（4-substituted acetamido-phenyl）-4,5-dihydro-3（2H）-py- ridazinones with different heterocylic groups. Methods: Ten target compounds were designed and synthesized.All of them were con- firmed by 1H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggre- gative activity to a certain extent.Compound （5）,（9） and （10） were better than MCI-154 in vitro. Conclusion:: The stereospecifie blockade and hydrophilieity of different heterocylic groups impacted the antiplatelet aggregative activity.

SUN Liang, HUANG Xiao-jin, FAN Song-jie, YU Shi-chong, WU Qiu-ye. Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 278-281.
Citation: SUN Liang, HUANG Xiao-jin, FAN Song-jie, YU Shi-chong, WU Qiu-ye. Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 278-281.
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