Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones
- Received Date: 2008-04-14
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Key words:
- synthesis /
- pyridazinones /
- antiplatelet aggregation
Abstract: Objective: To study the antiplatelet aggregative aclivity nf 6-(4-substituted acetamido-phenyl)-4,5-dihydro-3(2H)-py- ridazinones with different heterocylic groups. Methods: Ten target compounds were designed and synthesized.All of them were con- firmed by 1H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggre- gative activity to a certain extent.Compound (5),(9) and (10) were better than MCI-154 in vitro. Conclusion:: The stereospecifie blockade and hydrophilieity of different heterocylic groups impacted the antiplatelet aggregative activity.
Citation: | SUN Liang, HUANG Xiao-jin, FAN Song-jie, YU Shi-chong, WU Qiu-ye. Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (4): 278-281. |