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XU Shan-cao, GAO Yue-jin, GU Yan-ling. Different relaxation effect of cinnarizine and nimodipine on isolated arteries[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 343-345,349.
Citation: XU Shan-cao, GAO Yue-jin, GU Yan-ling. Different relaxation effect of cinnarizine and nimodipine on isolated arteries[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 343-345,349.

Different relaxation effect of cinnarizine and nimodipine on isolated arteries

  • Received Date: 2006-11-29
  • Objective:This study was designed to investigate the different relaxation effect of cinnarizine and nimodipine on isolated arteries.Methods:Arteries were isolated from sixteen male Sprague-Dawley rats weighing 220~250 g,carefully dissected from sur- rounding fat and connective tissues,and cut into 2~3 mm-long circular segments.These segments were initially contracted with pheny- lephrine(1μM).When the contraction reached a steady state,cumulative concentration-respense(CR)curves to cinnarizine or ni- modipine were obtained by adding increasing concentrations to the segments that functional endothelium was present or absent.Re- sults:Both cinnarizine and nimodipine produced concentration-dependent relaxation on the segments that functional endothelium was present or absent.Nimodipine produced stronger relaxation on endothelium complete segments than on the endothelium removal ones. Cinnarizine produced a same relaxation on endothelium-complete segments and endothelium-removed ones.Conclusion:Cinnarizine and nimodipine produced different relaxation effects on endothelium-complete segments and endothelium-removed ones.The differ- ence between cinnarizine and nimodipine was depended on the integrity of the vascular endothelium.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Different relaxation effect of cinnarizine and nimodipine on isolated arteries

Abstract: Objective:This study was designed to investigate the different relaxation effect of cinnarizine and nimodipine on isolated arteries.Methods:Arteries were isolated from sixteen male Sprague-Dawley rats weighing 220~250 g,carefully dissected from sur- rounding fat and connective tissues,and cut into 2~3 mm-long circular segments.These segments were initially contracted with pheny- lephrine(1μM).When the contraction reached a steady state,cumulative concentration-respense(CR)curves to cinnarizine or ni- modipine were obtained by adding increasing concentrations to the segments that functional endothelium was present or absent.Re- sults:Both cinnarizine and nimodipine produced concentration-dependent relaxation on the segments that functional endothelium was present or absent.Nimodipine produced stronger relaxation on endothelium complete segments than on the endothelium removal ones. Cinnarizine produced a same relaxation on endothelium-complete segments and endothelium-removed ones.Conclusion:Cinnarizine and nimodipine produced different relaxation effects on endothelium-complete segments and endothelium-removed ones.The differ- ence between cinnarizine and nimodipine was depended on the integrity of the vascular endothelium.

XU Shan-cao, GAO Yue-jin, GU Yan-ling. Different relaxation effect of cinnarizine and nimodipine on isolated arteries[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 343-345,349.
Citation: XU Shan-cao, GAO Yue-jin, GU Yan-ling. Different relaxation effect of cinnarizine and nimodipine on isolated arteries[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 343-345,349.

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