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FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
Citation: FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.

Content determination of citrate in sodium citrate injection for catheter locking by HPLC

  • Received Date: 2007-09-27
  • Objective:To establish a content determination method of citrate in sodium citrate injection for catheter locking. Methods:HPLC was used to determine citrate on Diamonsil C18 column(250 mm×4.6 mm,5μm),using MeOH:0.05 mol/L KH2PO4(adjusted to pH 2.5~2.8 by H3PO4)(5:95,v:v)as a mobile phase with a flow rate at 1.0 mL/min and UV wavelengh of 210 nm.Results:The calibration curve of citrate was line in the range of 0.5~6 mg/mL(r=0.999 9,n=5).The average recovery was 98.79% (RSD=1.08%).The relative contents of citrate in three batch of citrate in sodium citrate injection for catheter locking were 100.51%,98.22% and 97.78%,respectively.Conclusion:This method was simple,rapid,accurate and suitable for the quality control of citrate.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 30.4 %其他: 30.4 %其他: 3.2 %其他: 3.2 %China: 0.4 %China: 0.4 %United States: 0.2 %United States: 0.2 %[]: 0.4 %[]: 0.4 %三明: 0.2 %三明: 0.2 %上海: 1.1 %上海: 1.1 %乌贝兰迪亚: 0.4 %乌贝兰迪亚: 0.4 %北京: 11.0 %北京: 11.0 %南京: 0.4 %南京: 0.4 %台拉登: 0.2 %台拉登: 0.2 %广州: 0.6 %广州: 0.6 %张家口: 0.2 %张家口: 0.2 %成都: 0.8 %成都: 0.8 %杭州: 0.6 %杭州: 0.6 %泰州: 0.2 %泰州: 0.2 %淄博: 0.8 %淄博: 0.8 %湖州: 0.2 %湖州: 0.2 %石家庄: 0.2 %石家庄: 0.2 %芒廷维尤: 33.8 %芒廷维尤: 33.8 %萨拉曼卡: 0.4 %萨拉曼卡: 0.4 %西宁: 14.2 %西宁: 14.2 %阿纳波利斯: 0.4 %阿纳波利斯: 0.4 %其他其他ChinaUnited States[]三明上海乌贝兰迪亚北京南京台拉登广州张家口成都杭州泰州淄博湖州石家庄芒廷维尤萨拉曼卡西宁阿纳波利斯Highcharts.com
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Content determination of citrate in sodium citrate injection for catheter locking by HPLC

Abstract: Objective:To establish a content determination method of citrate in sodium citrate injection for catheter locking. Methods:HPLC was used to determine citrate on Diamonsil C18 column(250 mm×4.6 mm,5μm),using MeOH:0.05 mol/L KH2PO4(adjusted to pH 2.5~2.8 by H3PO4)(5:95,v:v)as a mobile phase with a flow rate at 1.0 mL/min and UV wavelengh of 210 nm.Results:The calibration curve of citrate was line in the range of 0.5~6 mg/mL(r=0.999 9,n=5).The average recovery was 98.79% (RSD=1.08%).The relative contents of citrate in three batch of citrate in sodium citrate injection for catheter locking were 100.51%,98.22% and 97.78%,respectively.Conclusion:This method was simple,rapid,accurate and suitable for the quality control of citrate.

FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
Citation: FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.

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