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Volume 26 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (5): 364-366

SHUI Qing-hua, SU Huai, LI Jin, LAN Wei-wei, WU Li-fen. Effect of pH on the stability of brimonidine tartrate eye drops[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 364-366.
Citation: SHUI Qing-hua, SU Huai, LI Jin, LAN Wei-wei, WU Li-fen. Effect of pH on the stability of brimonidine tartrate eye drops[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 364-366.
shu

Effect of pH on the stability of brimonidine tartrate eye drops

  • Shandong Bausch & Lomb Freda Pharmaceuticals Co.,Lid.,Jinan 250014,China

  • Received Date: 2007-12-17
  • Objective:To study the effect of pH on stability of brimonidine tartrate eye drops and to determine the optimal range of pH and storage conditions of it.Methods:HPLC methed was used for the determination of content and related substance of brimonidine tartrae eye drops.The stability of the preparation at high temperature and intense light illumination was studied.Results:Brimonidine tartrae eye drops was sensitive to high temperature and strong illumination.The stability of the preparation would get lower with the in- crease of pH.Conclusion:The optimum pH of the preparation was partial to acidity,and the optimum storage condition was low tem- perature and away from light.
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Effect of pH on the stability of brimonidine tartrate eye drops

  • Shandong Bausch & Lomb Freda Pharmaceuticals Co.,Lid.,Jinan 250014,China
  • Received Date: 2007-12-17

Abstract: Objective:To study the effect of pH on stability of brimonidine tartrate eye drops and to determine the optimal range of pH and storage conditions of it.Methods:HPLC methed was used for the determination of content and related substance of brimonidine tartrae eye drops.The stability of the preparation at high temperature and intense light illumination was studied.Results:Brimonidine tartrae eye drops was sensitive to high temperature and strong illumination.The stability of the preparation would get lower with the in- crease of pH.Conclusion:The optimum pH of the preparation was partial to acidity,and the optimum storage condition was low tem- perature and away from light.

SHUI Qing-hua, SU Huai, LI Jin, LAN Wei-wei, WU Li-fen. Effect of pH on the stability of brimonidine tartrate eye drops[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 364-366.
Citation: SHUI Qing-hua, SU Huai, LI Jin, LAN Wei-wei, WU Li-fen. Effect of pH on the stability of brimonidine tartrate eye drops[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 364-366.
shu

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