Synthesis and antiplatelet aggregative activity of 6-[4-(substituted amino acetamido-phenyl)]-4,5-dihydro-3(2H)-pyridazinones
- Received Date: 2008-05-14
Abstract: Objective: To synthesize new pyridazinone derivatives substituted by different amino groups. Methods: Eight target compounds were designed and synthesized by inletting different substituted amino groups connecting through the acetyl fragment.All of them were confirmed by 1 H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported for the first time.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggregative activity to a certain extent.Compounds(1),(3)and(8)have better activeties;compound (3)showed a 6 times higher activity than that of MCI-154. Conclusion: Inletting different substituted amino groups can enhance the antiplatelet aggregation activity of the compounds.
Citation: | CHAI Xiao-yun, ZHANG Chen-xi, HU Hong-gang, ZHAO Qing-jie, DAN Zhi-gang, ZOU Yan, YU Shi-chong, WU Qiu-ye. Synthesis and antiplatelet aggregative activity of 6-[4-(substituted amino acetamido-phenyl)]-4,5-dihydro-3(2H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 444-446,467. |