Study on the synthesis of replaced imidazole
- Received Date: 2008-09-28
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Key words:
- replaced imidazole /
- synthesis /
- orthogonal experimental design
Abstract: Objective: To optimize the synthesis of replaced imidazole. Methods: Orthogonal experimental design was used and the influence of temperature,reactant ratio and solvent on the yield were investigated. Results: Reactant ratio was more important than the others.The yield was improved from less than 10%to 42.5%. Conclusion: The optimal preparation procedure is stable and available for industrial production.
Citation: | LI Ya-nan, LI Yao-wu, ZHEN Can-hui, LU jia-guo, TANG Hui, ZHANG Jue, ZHOU You-jun. Study on the synthesis of replaced imidazole[J]. Journal of Pharmaceutical Practice and Service, 2008, (6): 447-449. |