Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein
- Received Date: 2008-06-03
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Key words:
- bvastatin /
- oxidized low density lipoprotein /
- hypoxia inducible factor 1
Abstract: Objective :To study the effects of expression of hypoxia inducible 1 alpha(HIF-1α) on U937 cell stimulated by oxidized low density lipoprotein(ox-LDL) and the influence of lovastatin. Methods :Foam cell formation was tested by oil red O-stain analysis,and expression of HIF-1α was measured by the method of Real-time PCR and Western blotting. Results :Foam cell was not formed by U937 cell without ox-LDL stimulating;U937 cell with ox-LDL stimulating for 24 h was transformed to foam cell.After treated with ox-LDL,the expression of HIF-1αwas markedly increased on U937 cells;with the combined treatment of lovastatin ox-LDL,the expression of HIF-1αwas significantly decreased,and this inhibitory effect was dose dependant. Conclusion :Lovasatin could inhibit both the expression of HIF-1αon U937 and the foam cell formation induced by ox-LDL.
Citation: | JIANG Guo-jun, ZHANG LI, LI Tie-jun, QIU Yan, LOU Yi-jia. Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 170-173. |