Preparation and physicochemical properties of kaempferol-3-O-rutinoside phospholipids complex
- Received Date: 2009-02-19
Abstract: Objective :To prepare kaempferol-3-O-rutinoside phospholipid complex and study its physic chemical properties. Methods :Solubility and water oil distribution coefficient of the complex were studied,and compared with kaempferol-3-O-rutinoside. Results :There were a great improvements in the solubility of kaempferol-3-O-rutinoside phospholipid complex both in water and in n-octanol.Some differences of apparent oil/water distribution coefficients in the systems consisted of different pH water and n-octanol were found between the complex and kaempferol-3-O-rutinoside. Conclusion :The drug-phospholipid complexes may show some superior chemico-physical properties and enhance the absorption of the drugs.
Citation: | FU Qiu-sheng, YI Shu-zhen. Preparation and physicochemical properties of kaempferol-3-O-rutinoside phospholipids complex[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 186-188. |