Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.
Citation: GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.

Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers

  • Received Date: 2008-12-25
  • Objective :To study the pharmacokinetics of minocycline hydrochloride in 10 Chinese healthy volunteers after a single intravenous administration of 200mg minocycline. Methods :Minocycline hydrochloride concentration in plasma was measured by an improved HPLC method,and the pharmacokinetic parameters were calculated. Results :After single dose administration of 200 mg minocycline,the main pharmacokinetic parameters t1/2,Cmax,tmax,AUC0→72h,AUC0→∞were(18.1±4.07) h,(4.744±0.887) mg/L,2.0 h,(75.71 ±10.68) mg·h/L,(79.90±12.81) mg·h/L,respectively. Conclusion :The main pharmacokinetic parameters of minocycline are consistent with those reported previously.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(3238) PDF downloads(623) Cited by()

Related
Proportional views

Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers

Abstract: Objective :To study the pharmacokinetics of minocycline hydrochloride in 10 Chinese healthy volunteers after a single intravenous administration of 200mg minocycline. Methods :Minocycline hydrochloride concentration in plasma was measured by an improved HPLC method,and the pharmacokinetic parameters were calculated. Results :After single dose administration of 200 mg minocycline,the main pharmacokinetic parameters t1/2,Cmax,tmax,AUC0→72h,AUC0→∞were(18.1±4.07) h,(4.744±0.887) mg/L,2.0 h,(75.71 ±10.68) mg·h/L,(79.90±12.81) mg·h/L,respectively. Conclusion :The main pharmacokinetic parameters of minocycline are consistent with those reported previously.

GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.
Citation: GAO Shou-hong, WEN Yan, WU Rong, JIN Xiao-ling, YUN Yun-lei, LI Jing-xian, MIAO Hai-jun. Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 193-194,200.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return