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JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: MENG Hui, XU Yong. Optimized formulation of human serum albumin injectable gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 254-257.

Optimized formulation of human serum albumin injectable gel

  • Received Date: 2008-08-28
  • Objective :To prepare human serum albumin(HSA) injectable gel.To optimize the formulations of injectable gel by a central composite design/response surface methodology. Methods : Injectable gel loaded HSA were prepared with poly(lactic-co-glycolic acid)(PLGA) as carrier material and N-methyl-2-pyrrolidone(NMP) and benzyl benzoate(BB)as co-solvent.Independent variables were PLGA content and the content of co-solvent,and in vitro release was dependent variable.Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables.Response surfaces were delineated according to best-fit mathematic models,and optimum formulations were selected thereform.Prediction was carried out through comparing the observed and predicted values. Results :The trinomial fitting equations of indexes were all superior to their multi-linear regression equations,and the predictive values in the established mathematical model were in good conformity with the experimental values. Conclusion :Central composite design/response surface method shows a good predictability in optimizing the formula technology of BDNF-loaded PLGA nanoparticles.
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    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 83.1 %FULLTEXT: 83.1 %META: 15.7 %META: 15.7 %PDF: 1.3 %PDF: 1.3 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 19.9 %其他: 19.9 %其他: 0.2 %其他: 0.2 %China: 0.6 %China: 0.6 %United States: 0.2 %United States: 0.2 %[]: 0.2 %[]: 0.2 %上海: 0.6 %上海: 0.6 %北京: 9.3 %北京: 9.3 %杭州: 0.2 %杭州: 0.2 %梧州: 0.2 %梧州: 0.2 %海得拉巴: 0.8 %海得拉巴: 0.8 %芒廷维尤: 18.4 %芒廷维尤: 18.4 %西宁: 49.2 %西宁: 49.2 %其他其他ChinaUnited States[]上海北京杭州梧州海得拉巴芒廷维尤西宁Highcharts.com
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Optimized formulation of human serum albumin injectable gel

Abstract: Objective :To prepare human serum albumin(HSA) injectable gel.To optimize the formulations of injectable gel by a central composite design/response surface methodology. Methods : Injectable gel loaded HSA were prepared with poly(lactic-co-glycolic acid)(PLGA) as carrier material and N-methyl-2-pyrrolidone(NMP) and benzyl benzoate(BB)as co-solvent.Independent variables were PLGA content and the content of co-solvent,and in vitro release was dependent variable.Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables.Response surfaces were delineated according to best-fit mathematic models,and optimum formulations were selected thereform.Prediction was carried out through comparing the observed and predicted values. Results :The trinomial fitting equations of indexes were all superior to their multi-linear regression equations,and the predictive values in the established mathematical model were in good conformity with the experimental values. Conclusion :Central composite design/response surface method shows a good predictability in optimizing the formula technology of BDNF-loaded PLGA nanoparticles.

JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: MENG Hui, XU Yong. Optimized formulation of human serum albumin injectable gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 254-257.

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