Studies on synthesis and antiviral activities of 5-substituted pyrimidine acyclic nucleoside phosphonate compounds on HBV
- Received Date: 2009-03-17
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Key words:
- 5-substituted pyrimidine /
- chemical synthesis /
- acyclic nucleotide /
- anti-HBV activity
Abstract: Objective :To study on synthesis and antiviral activities of 5-substituted pyrimidine acyclic nucleoside phosphonate compounds on HBV. Methods : Starting with substituted pyrimidine,we synthesized 8 firstly reported compounds 1a~1h.Preliminary pharmacological test was made on HBV. Results :TThe test results show the inhibitory rate of targeted compounds on HBsAg and HBeAg is normal,but 1d is higher than lamivudine. Conclusion :5-substituted pyrimidine acyclic nucleoside phosphonate compounds keep the normal activities on HBV and introduce long chain of chloroformate at N6 of pyrimidine shows better activity.
Citation: | FENG Ji-lu, WU Guang, YU Jian-xin, LIU Jia, NIU Chun-juan, LI Ke. Studies on synthesis and antiviral activities of 5-substituted pyrimidine acyclic nucleoside phosphonate compounds on HBV[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 328-331. |