Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 5
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 334-336,352

WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
Citation: WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
shu

Therapeutical effects of Danhong for injection on myocardial infarction in dogs

  • 1.

    Department of pharmacy, 169th Hospital of PLA, Hengyang 421002, China

  • 2.

    Health Care Department of Management and Logistic Support Department, Headquartes' of General Staff, PLA, Beijing 100082, China

  • 3.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2009-04-29
  • Objective :To investigate the therapeutical effects of Danhong for injection on myocardial infarction model induced by coronary artery ligation in dogs. Methods : The models of myocardial infarction were produced by ligation of the left anterior descending coronary artery in the anaesthetized dogs.The extent of myocardial ischemia and infarction was determined by means of epicardial mapping and N-BT staining.The parameters of lactate dehydrogenase and creatine kinase were also determined in the serums of dogs. Results :Danhong for injection(2、6 and 12mg/kg) by the way of intravenous injection obviously reduced the extent of myocardial infarction and the myocardial ischemia level at a dose-dependent manner.Increase of ∑-ST and N-ST,and the range of myocardial infarction caused by ligating coronary artery in dogs were obviously reduced by Danhong for injection.The level of LDH and CK in the serum of dogs were also decreased by Danhong for injection.Conclusions:The results show that Danhong for injection has significant protective effects on myocardial infarction in dogs.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2247) PDF downloads(781) Cited by()

Related
Proportional views

Therapeutical effects of Danhong for injection on myocardial infarction in dogs

  • 1. Department of pharmacy, 169th Hospital of PLA, Hengyang 421002, China
  • 2. Health Care Department of Management and Logistic Support Department, Headquartes' of General Staff, PLA, Beijing 100082, China
  • 3. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2009-04-29

Abstract: Objective :To investigate the therapeutical effects of Danhong for injection on myocardial infarction model induced by coronary artery ligation in dogs. Methods : The models of myocardial infarction were produced by ligation of the left anterior descending coronary artery in the anaesthetized dogs.The extent of myocardial ischemia and infarction was determined by means of epicardial mapping and N-BT staining.The parameters of lactate dehydrogenase and creatine kinase were also determined in the serums of dogs. Results :Danhong for injection(2、6 and 12mg/kg) by the way of intravenous injection obviously reduced the extent of myocardial infarction and the myocardial ischemia level at a dose-dependent manner.Increase of ∑-ST and N-ST,and the range of myocardial infarction caused by ligating coronary artery in dogs were obviously reduced by Danhong for injection.The level of LDH and CK in the serum of dogs were also decreased by Danhong for injection.Conclusions:The results show that Danhong for injection has significant protective effects on myocardial infarction in dogs.

WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
Citation: WANG Ke-bing, ZOU Li-hua, ZHANG Zhi-qiang. Therapeutical effects of Danhong for injection on myocardial infarction in dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 334-336,352.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return