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Volume 27 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 337-339,372

LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
Citation: LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
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Studies on glycolic acid injection resulting in local necrosis of rat livers

  • 1.

    Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2009-03-11
  • Objective :To observe local necrosis of rat livers resulted from glycolic acid injection and compare necrosis effects resulted from glycolic acid injection and ethanol injection. Methods :After injections of a series of concentrations of glycolic acid and ethanol into rat livers,the mean diameters and the pathologic histology examinations of coagulation necrosis in rat livers were detected. Results :Necrosis occurred around the injection site of glycolic acid.The mean diameter of the necrotic area caused by 5%、10%、15%、20%、30%、40%and 50%glycolic acid was significantly larger than that caused by ethanol(P< 0.05),and pathohistology confirmed that the necrosis was more serious in the former group. Conclusion :Glycolic acid could cause local necrosis of liver,and might be used in clinical practices in the future as a substitute of ethanol for the treatment of liver cancer.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies on glycolic acid injection resulting in local necrosis of rat livers

  • 1. Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2009-03-11

Abstract: Objective :To observe local necrosis of rat livers resulted from glycolic acid injection and compare necrosis effects resulted from glycolic acid injection and ethanol injection. Methods :After injections of a series of concentrations of glycolic acid and ethanol into rat livers,the mean diameters and the pathologic histology examinations of coagulation necrosis in rat livers were detected. Results :Necrosis occurred around the injection site of glycolic acid.The mean diameter of the necrotic area caused by 5%、10%、15%、20%、30%、40%and 50%glycolic acid was significantly larger than that caused by ethanol(P< 0.05),and pathohistology confirmed that the necrosis was more serious in the former group. Conclusion :Glycolic acid could cause local necrosis of liver,and might be used in clinical practices in the future as a substitute of ethanol for the treatment of liver cancer.

LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
Citation: LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
shu

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