Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

XU Jie, WANG Ju, FENG Nian-ping, ZHAO Ji-hui, YU Yan-yan, TAN Rong. Optimized preparation of oridonin-loaded nanoparticles by central composite design and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 345-348,369.
Citation: XU Jie, WANG Ju, FENG Nian-ping, ZHAO Ji-hui, YU Yan-yan, TAN Rong. Optimized preparation of oridonin-loaded nanoparticles by central composite design and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 345-348,369.

Optimized preparation of oridonin-loaded nanoparticles by central composite design and response surface method

  • Received Date: 2009-02-18
  • Objective : To optimize the formulation of oridonin-loaded PLA nanoparticles with modified spontaneous emulsification solvent diffusion method. Methods :Applying central composite design and response surface method,choose the concentration of drug in organic phase,the concentration of PLA in organic phase and the ratio of water phase to organic phase as the influence factors.The evaluation parameters included entrapment efficiency,drug loading rate and particle size.Experiments were done on the theory of central composite design.The data were simulated using multi-linear equation and second-order polynomial equation.The possibly optimal formulation was predicted by response surface method. Results : TThe range of the optimal conditions were the concentration of drug in organic phase 0.5~0.8 mg/mL,the concentration of PLA in organic phase 1.6~2.6 mg/mL,the ratio of water phase to organic phase 1~1.5 According to the optimal conditions,the mean particle size,entrapment efficiency and drug loading rate were 98.5 nm,(28.86 ±0.93) % and(8.23 ±0.35) %,respectively. Conclusion :The central composite design and response surface method are useful for the optimization of preparing oridonin-loaded PLA nanoparticles.The established model could predict the parameter of the formulations exactly and properly.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2090) PDF downloads(892) Cited by()

Related
Proportional views

Optimized preparation of oridonin-loaded nanoparticles by central composite design and response surface method

Abstract: Objective : To optimize the formulation of oridonin-loaded PLA nanoparticles with modified spontaneous emulsification solvent diffusion method. Methods :Applying central composite design and response surface method,choose the concentration of drug in organic phase,the concentration of PLA in organic phase and the ratio of water phase to organic phase as the influence factors.The evaluation parameters included entrapment efficiency,drug loading rate and particle size.Experiments were done on the theory of central composite design.The data were simulated using multi-linear equation and second-order polynomial equation.The possibly optimal formulation was predicted by response surface method. Results : TThe range of the optimal conditions were the concentration of drug in organic phase 0.5~0.8 mg/mL,the concentration of PLA in organic phase 1.6~2.6 mg/mL,the ratio of water phase to organic phase 1~1.5 According to the optimal conditions,the mean particle size,entrapment efficiency and drug loading rate were 98.5 nm,(28.86 ±0.93) % and(8.23 ±0.35) %,respectively. Conclusion :The central composite design and response surface method are useful for the optimization of preparing oridonin-loaded PLA nanoparticles.The established model could predict the parameter of the formulations exactly and properly.

XU Jie, WANG Ju, FENG Nian-ping, ZHAO Ji-hui, YU Yan-yan, TAN Rong. Optimized preparation of oridonin-loaded nanoparticles by central composite design and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 345-348,369.
Citation: XU Jie, WANG Ju, FENG Nian-ping, ZHAO Ji-hui, YU Yan-yan, TAN Rong. Optimized preparation of oridonin-loaded nanoparticles by central composite design and response surface method[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 345-348,369.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return