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Volume 27 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 359-361

LIU Min, GU Zhuo-liang, ZHANG Xiao-dan, ZHOU Guo-hua. Determination of illegal ingredient diclofenacpotassium in TCM by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 359-361.
Citation: LIU Min, GU Zhuo-liang, ZHANG Xiao-dan, ZHOU Guo-hua. Determination of illegal ingredient diclofenacpotassium in TCM by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 359-361.
shu

Determination of illegal ingredient diclofenacpotassium in TCM by capillary electrophoresis

  • 1.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Institute for Drug and Instrument Control, Nanjing Military Area, Nanjing 210002, China

  • Received Date: 2009-03-25
  • Objective :To establish a capillary electrophoresis(CE) method for determining the illegally added ingredient diclofenac potassium in TCM,Shuguning tablet. Methods : CE was used for the separation by using the uncoaded capillary(75 μm×50 cm) and buffer of 25 mmol/L Na2HPO4(pH 6.50±0.02).The applied voltage was 25 kV at 25℃.The sample was injected for 5s at 0.5psi and the detection wavelength was at 275 nm. Results :Linear range was from 0.010 g/L to 0.200 g/L(r=0.998 4),the average recovery was 100.6% with the RSD of 4.39%. Conclusion : This method is simple,rapid,reliable and accurate for quantifying the illegally added diclofenac potassium in Shuguning tablets.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of illegal ingredient diclofenacpotassium in TCM by capillary electrophoresis

  • 1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Institute for Drug and Instrument Control, Nanjing Military Area, Nanjing 210002, China
  • Received Date: 2009-03-25

Abstract: Objective :To establish a capillary electrophoresis(CE) method for determining the illegally added ingredient diclofenac potassium in TCM,Shuguning tablet. Methods : CE was used for the separation by using the uncoaded capillary(75 μm×50 cm) and buffer of 25 mmol/L Na2HPO4(pH 6.50±0.02).The applied voltage was 25 kV at 25℃.The sample was injected for 5s at 0.5psi and the detection wavelength was at 275 nm. Results :Linear range was from 0.010 g/L to 0.200 g/L(r=0.998 4),the average recovery was 100.6% with the RSD of 4.39%. Conclusion : This method is simple,rapid,reliable and accurate for quantifying the illegally added diclofenac potassium in Shuguning tablets.

LIU Min, GU Zhuo-liang, ZHANG Xiao-dan, ZHOU Guo-hua. Determination of illegal ingredient diclofenacpotassium in TCM by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 359-361.
Citation: LIU Min, GU Zhuo-liang, ZHANG Xiao-dan, ZHOU Guo-hua. Determination of illegal ingredient diclofenacpotassium in TCM by capillary electrophoresis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 359-361.
shu

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