Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 5
. 
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 365-366,387

LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation: CAI Lin, YAN Ju-jiao, LI Heng. Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 365-366,387.
shu

Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography

  • 1.

    181th Hospital of Chinese People's Libration Army, Guilin 541002, China

  • 2.

    Wuhan Institute for Drug Control, Wuhan 430012, China

  • Received Date: 2009-08-16
  • Objective :To establish a method for determination of five residual solvents in gatifloxacin. Methods : The residual organic solvents which are ethanol,acetonitrile,dichloromethane,ethyl acetate,toluene were quantitatively determined by headspace GC on DM-624 column,90%DMF as solvent media,with FID detector,high purity nitrogen as the carrier gas. Results : Five residual solvents were completely separated.There was a good linearity(r=0.999 7～0.999 9).The detection limit of ethanol,acetonitrile,Dichloromethane,ethyl acetate,toluene were all less than 3μg/g;the RSD of precision was less than 5%;the average recovery rate of the preparation was in the range of 94.8%～98.6%. Conclusion :The method is simple,rapid,sensitive and can be used for the quality control of gatifloxacin.
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-040123456Highcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 94.2 %FULLTEXT: 94.2 %META: 5.8 %META: 5.8 %FULLTEXTMETAHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 27.6 %其他: 27.6 %China: 1.0 %China: 1.0 %上海: 1.5 %上海: 1.5 %兰州: 0.3 %兰州: 0.3 %北京: 12.7 %北京: 12.7 %南平: 0.3 %南平: 0.3 %台州: 0.3 %台州: 0.3 %天津: 0.3 %天津: 0.3 %宜春: 0.3 %宜春: 0.3 %广州: 1.3 %广州: 1.3 %成都: 0.3 %成都: 0.3 %梧州: 0.3 %梧州: 0.3 %沈阳: 0.3 %沈阳: 0.3 %泉州: 0.3 %泉州: 0.3 %济南: 0.3 %济南: 0.3 %深圳: 0.3 %深圳: 0.3 %湖州: 1.3 %湖州: 1.3 %石家庄: 0.3 %石家庄: 0.3 %芒廷维尤: 15.4 %芒廷维尤: 15.4 %莫斯科: 0.5 %莫斯科: 0.5 %西宁: 34.7 %西宁: 34.7 %西安: 0.3 %西安: 0.3 %达尔斯: 0.3 %达尔斯: 0.3 %郑州: 0.3 %郑州: 0.3 %金华: 0.3 %金华: 0.3 %其他China上海兰州北京南平台州天津宜春广州成都梧州沈阳泉州济南深圳湖州石家庄芒廷维尤莫斯科西宁西安达尔斯郑州金华Highcharts.com
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2374) PDF downloads(711) Cited by()

Related
Proportional views

Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography

  • 1. 181th Hospital of Chinese People's Libration Army, Guilin 541002, China
  • 2. Wuhan Institute for Drug Control, Wuhan 430012, China
  • Received Date: 2009-08-16

Abstract: Objective :To establish a method for determination of five residual solvents in gatifloxacin. Methods : The residual organic solvents which are ethanol,acetonitrile,dichloromethane,ethyl acetate,toluene were quantitatively determined by headspace GC on DM-624 column,90%DMF as solvent media,with FID detector,high purity nitrogen as the carrier gas. Results : Five residual solvents were completely separated.There was a good linearity(r=0.999 7～0.999 9).The detection limit of ethanol,acetonitrile,Dichloromethane,ethyl acetate,toluene were all less than 3μg/g;the RSD of precision was less than 5%;the average recovery rate of the preparation was in the range of 94.8%～98.6%. Conclusion :The method is simple,rapid,sensitive and can be used for the quality control of gatifloxacin.

LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation: CAI Lin, YAN Ju-jiao, LI Heng. Determination of residual solvents in gatifloxacin by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 365-366,387.
shu

    HTML

Catalog

  • HTML

版权所有：《药学实践与服务》编辑委员会

Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号 沪ICP备05003363号-1

Supported by: Beijing Renhe Information Technology Co., Ltd.  

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return