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Volume 27 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 367-369

GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
Citation: GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
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Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel

  • 1.

    Undergraduate of 2005, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, 305th Hospital of PLA, Beijing 100017, China

  • 3.

    Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China

  • Received Date: 2009-04-03
  • Objective :To prepare cetirizine hydrochloride gel and study its skin penetration in vitro. Methods : Cetirizine gel was prepared with carbopol 940 as base material.Using Franz diffusion cell and excised rat skin in vitro as transdermal barrier.The cumulative permeation quantity of cetirizine was determined by HPLC. Results :The penetration equation of cetirizine gel was Q=110.03t+17.17(r=0.99). Conclusion :The penetration of cetirizine from the gel through the rat skin followed first-order kinetics.
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Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel

  • 1. Undergraduate of 2005, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, 305th Hospital of PLA, Beijing 100017, China
  • 3. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China
  • Received Date: 2009-04-03

Abstract: Objective :To prepare cetirizine hydrochloride gel and study its skin penetration in vitro. Methods : Cetirizine gel was prepared with carbopol 940 as base material.Using Franz diffusion cell and excised rat skin in vitro as transdermal barrier.The cumulative permeation quantity of cetirizine was determined by HPLC. Results :The penetration equation of cetirizine gel was Q=110.03t+17.17(r=0.99). Conclusion :The penetration of cetirizine from the gel through the rat skin followed first-order kinetics.

GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
Citation: GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
shu

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