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Volume 28 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 7-10

CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
Citation: CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
shu

Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability

  • 1.

    Department of pharmaceutics,School of pharmacy,Second Military Medical University,Shanghai 200433,China

  • 2.

    06 sessions of Unergraduate pharmacy Students,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2009-09-16
  • Rev Recd Date: 2009-10-14
  • Objective To investigate the feasibility of temozolomide replacement of vitamin C and penicillin to evaluate the drug stability for students,experiment;to establish the experimental method to predict the validity duration of temozolomide at room temperature and examine the impact of pH on the validity duration. Methods The concentration of temozolomide was assayed by high performance liquid chromatography(HPLC);the rate equation of first order reaction and Arrhenius equation were used to calculate the correlation parameters. Results Temozolomide was stable under the condition of acidic environment,not under the condition of high temperature,or alkaline environment,respectively;the pH value had a great impact on the drug stability;and the validity duration of temozolomide is about 21 days at room temperature. Conclusion The operation was simple and convenient,and temozolomide was suitable as a model drug to evaluate the drug stability for students,experiment.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability

  • 1. Department of pharmaceutics,School of pharmacy,Second Military Medical University,Shanghai 200433,China
  • 2. 06 sessions of Unergraduate pharmacy Students,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2009-09-16
  • Rev Recd Date: 2009-10-14

Abstract: Objective To investigate the feasibility of temozolomide replacement of vitamin C and penicillin to evaluate the drug stability for students,experiment;to establish the experimental method to predict the validity duration of temozolomide at room temperature and examine the impact of pH on the validity duration. Methods The concentration of temozolomide was assayed by high performance liquid chromatography(HPLC);the rate equation of first order reaction and Arrhenius equation were used to calculate the correlation parameters. Results Temozolomide was stable under the condition of acidic environment,not under the condition of high temperature,or alkaline environment,respectively;the pH value had a great impact on the drug stability;and the validity duration of temozolomide is about 21 days at room temperature. Conclusion The operation was simple and convenient,and temozolomide was suitable as a model drug to evaluate the drug stability for students,experiment.

CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
Citation: CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
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