Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice
- Received Date: 2009-06-25
- Rev Recd Date: 2009-10-26
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Key words:
- morphine /
- conditioned place preference /
- behavioral sensitization
Abstract: Objective To observe the effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice. Methods Male mice were used as subjects.Total range of motion after treated with morphine and haloperidol were evaluated by locomotion activity video analysis system.Total range of motion,average velocity and number of shuttle were also evaluated after the psychical dependence established. Results Distance travelled was significantly increased after administration of morphine.Distance travelled was significantly decreased in haloperidol group.Haloperidol could intercept hyperlocomotion induced by morphine.After treated with morphine,time to the morphine side significantly increased.Distance travelled,average velocity and number of shuttle also decreased significantly. Conclusion Haloperidol could suppress behavioral sensitization induced by morphine.The dopamine system functions may be inhibited after conditioned place preference established.
Citation: | SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72. |