Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation
- Received Date: 2009-06-29
- Rev Recd Date: 2009-08-18
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Key words:
- renal transplantation,tacrolimus /
- MDR1 /
- genetic polymorphism /
- concentration/dose /
- efficacy /
- adverse reaction /
Abstract: Objective To investigate the impact of MDR1C3435T genetic polymorphism on the concentration/dose(C/D) ratio,acute rejection and adverse effect of tacrolimus(FK506)in the renal patients after transplantation. Methods The MDR1C3435T genotype was determined by PCR-RFLP method.The differences of C/D ratio,acute rejection and adverse reaction were compared among all of the genotype groups treated with FK506. Results There was no significant difference in the C/D ratio,rejection and adverse reaction of FK506 among MDR1C3435T genotype groups. Conclusion There was no significant relation between the C/D ratio,acute rejection and adverse reaction of FK506 and MDR1C3435T genetic polymorphism in the transplant patients.
Citation: | HOU Ming-ming, SONG Hong-tao, WANG Qing-hua, YANG Shun-liang, TAN Jian-ming. Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 29-31. |