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LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation:
CHEN Wei-zhong. Quantitative analysis of baicalin in Qinlan nasal drops by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 42-44.
Quantitative analysis of baicalin in Qinlan nasal drops by RP-HPLC
Department of Pharmacy,Fuzhou General Hospital of Nanjin Military Region,Fuzhou 350025,China
Received Date: 2009-04-22
Rev Recd Date:
2009-10-19
Abstract
Objective To develop RP-HPLC method for the determination of baicalin in Qinlan nasal drops. Methods The chromatographic analysis was performed on Gemini C18 110A(4.60 mm×250 mm,5 μm)column.The mobile phase was consisted of methanol-0.2% phosphoric acid solution(50: 50).The flow rate was 0.8 ml/min.The detection wavelength was set at 277 nm,with injection volume 10 μl. Results A good linearity was obtained over the range of 709.4～7094.0μg/ml(r=0.999 9).The average recovery of baicalin was 99.6%,with RSD 1.33%(n=9). Conclusion The method is simple,accurate,specific and will be used for the quality control of Qinlan nasal drops.
Abstract: Objective To develop RP-HPLC method for the determination of baicalin in Qinlan nasal drops. Methods The chromatographic analysis was performed on Gemini C18 110A(4.60 mm×250 mm,5 μm)column.The mobile phase was consisted of methanol-0.2% phosphoric acid solution(50: 50).The flow rate was 0.8 ml/min.The detection wavelength was set at 277 nm,with injection volume 10 μl. Results A good linearity was obtained over the range of 709.4～7094.0μg/ml(r=0.999 9).The average recovery of baicalin was 99.6%,with RSD 1.33%(n=9). Conclusion The method is simple,accurate,specific and will be used for the quality control of Qinlan nasal drops.
LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation:
CHEN Wei-zhong. Quantitative analysis of baicalin in Qinlan nasal drops by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 42-44.
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LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
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