Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel
- Received Date: 2009-12-29
- Rev Recd Date: 2010-02-10
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Key words:
- ginkgo biloba leaf extract /
- in-situ nasal gel /
- sorbefacients
Abstract: Objective To preparation of ginkgo biloba leaf in-situ nasal gel and exploration of the effect of sorbefacients on nasal mucosa Absorption. Methods Carbopol 934 and HPMC were used as gel matrix to prepare pH sensitive in-situ ginkgo biloba leaf nasal gel,whose viscosity,adhesion,and in vitro nasal mucosa Absorption were studied. Results The in-situ ginkgo biloba leaf gel can be best prepared with 0.8% of Carbopol 934 and 1.5% of HPMC as gel matrix.Three sorbefacients were studied.The sequence of their permeation rate were 1% of Azone > 1% of Twain-80 > 0.5% of Borneol.The drug Absorption rate increases as the Azone concentration increases,the it’s Absorption process fits Weibull equation. Conclusion The preparation technology of in-situ ginkgo biloba leaf nasal gel is viable.And Azone is the most effective sorbefacient for nasal mucosa Absorption.
Citation: | CUI Hai-zhen, LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, LI Zi-yan. Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 118-121. |