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Volume 28 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(2): 122-125

ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.
Citation: ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.
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Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery

  • 1.

    Second Military Medical University,Colledge of graduate students

  • 2.

    Second Military Medical University,Changhai Hospital

  • 3.

    Second Military Medical University,School of Pharmacy,Shanghai 200433,China

  • Received Date: 2010-01-04
  • Rev Recd Date: 2010-03-15
  • Objective To develop the pH-triggered levofloxacin hydrochloride in-situ forming eye gel. Methods The gel was formed carpool as gel base and hydroxypropyl methylcellulose(HPMC) as thickening agents,and was the foluma evaluated according to the viscosity,the in-situ gelling capacity and the content of levofloxacin hydrochloride. Results The optimized formulation was made by dissolving levofloxacin hydrochloride 0.1 g,HPMC E50LV 2.0 g,carbopol 0.3 g,Na2HPO4 0.35 g,NaH2PO4 0.45 g,NaCl 0.50 g,and ethylparaben 0.03 g in 100 ml water.The gels showed good sustained release characteristics in vitro. Conclusion The optimized formulation has a good reproducibility and can be used for preparation of pH-triggered levofloxacin hydrochloride in-situ forming eye gel.
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通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery

  • 1. Second Military Medical University,Colledge of graduate students
  • 2. Second Military Medical University,Changhai Hospital
  • 3. Second Military Medical University,School of Pharmacy,Shanghai 200433,China
  • Received Date: 2010-01-04
  • Rev Recd Date: 2010-03-15

Abstract: Objective To develop the pH-triggered levofloxacin hydrochloride in-situ forming eye gel. Methods The gel was formed carpool as gel base and hydroxypropyl methylcellulose(HPMC) as thickening agents,and was the foluma evaluated according to the viscosity,the in-situ gelling capacity and the content of levofloxacin hydrochloride. Results The optimized formulation was made by dissolving levofloxacin hydrochloride 0.1 g,HPMC E50LV 2.0 g,carbopol 0.3 g,Na2HPO4 0.35 g,NaH2PO4 0.45 g,NaCl 0.50 g,and ethylparaben 0.03 g in 100 ml water.The gels showed good sustained release characteristics in vitro. Conclusion The optimized formulation has a good reproducibility and can be used for preparation of pH-triggered levofloxacin hydrochloride in-situ forming eye gel.

ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.
Citation: ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.
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