Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.
Citation: ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.

Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery

  • Received Date: 2010-01-04
  • Rev Recd Date: 2010-03-15
  • Objective To develop the pH-triggered levofloxacin hydrochloride in-situ forming eye gel. Methods The gel was formed carpool as gel base and hydroxypropyl methylcellulose(HPMC) as thickening agents,and was the foluma evaluated according to the viscosity,the in-situ gelling capacity and the content of levofloxacin hydrochloride. Results The optimized formulation was made by dissolving levofloxacin hydrochloride 0.1 g,HPMC E50LV 2.0 g,carbopol 0.3 g,Na2HPO4 0.35 g,NaH2PO4 0.45 g,NaCl 0.50 g,and ethylparaben 0.03 g in 100 ml water.The gels showed good sustained release characteristics in vitro. Conclusion The optimized formulation has a good reproducibility and can be used for preparation of pH-triggered levofloxacin hydrochloride in-situ forming eye gel.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2754) PDF downloads(596) Cited by()

Related
Proportional views

Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery

Abstract: Objective To develop the pH-triggered levofloxacin hydrochloride in-situ forming eye gel. Methods The gel was formed carpool as gel base and hydroxypropyl methylcellulose(HPMC) as thickening agents,and was the foluma evaluated according to the viscosity,the in-situ gelling capacity and the content of levofloxacin hydrochloride. Results The optimized formulation was made by dissolving levofloxacin hydrochloride 0.1 g,HPMC E50LV 2.0 g,carbopol 0.3 g,Na2HPO4 0.35 g,NaH2PO4 0.45 g,NaCl 0.50 g,and ethylparaben 0.03 g in 100 ml water.The gels showed good sustained release characteristics in vitro. Conclusion The optimized formulation has a good reproducibility and can be used for preparation of pH-triggered levofloxacin hydrochloride in-situ forming eye gel.

ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.
Citation: ZHANG Zhi-qiang, ZHANG Wei, CHEN guang, ZHANG Minga, HUO Jun-bina, CUI Lei, CHU Hao-wen, Gao Jing. Preparation and in vitro release of pH-triggered levofloxacin hydrochloride in-situ forming gel for sustained ophthalmic delivery[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 122-125.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return