Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 2
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(2): 126-129,139

ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
Citation: ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
shu

Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug

  • 1.

    Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China

  • 2.

    Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China

  • 3.

    School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China

  • Received Date: 2009-10-24
  • Rev Recd Date: 2009-12-27
  • Objective To prepare the sirolimus sustained-release tablets and study the influence factor. Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation Methods on the release of sirolimus from matrix tablets were observed. Results Based on the Results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC(K4M),2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class. Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2570) PDF downloads(968) Cited by()

Related
Proportional views

Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug

  • 1. Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China
  • 2. Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China
  • 3. School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China
  • Received Date: 2009-10-24
  • Rev Recd Date: 2009-12-27

Abstract: Objective To prepare the sirolimus sustained-release tablets and study the influence factor. Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation Methods on the release of sirolimus from matrix tablets were observed. Results Based on the Results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC(K4M),2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class. Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.

ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
Citation: ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return