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Volume 28 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(2): 126-129,139

ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
Citation: ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
shu

Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug

  • 1.

    Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China

  • 2.

    Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China

  • 3.

    School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China

  • Received Date: 2009-10-24
  • Rev Recd Date: 2009-12-27
  • Objective To prepare the sirolimus sustained-release tablets and study the influence factor. Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation Methods on the release of sirolimus from matrix tablets were observed. Results Based on the Results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC(K4M),2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class. Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug

  • 1. Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China
  • 2. Deptment of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China
  • 3. School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China
  • Received Date: 2009-10-24
  • Rev Recd Date: 2009-12-27

Abstract: Objective To prepare the sirolimus sustained-release tablets and study the influence factor. Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation Methods on the release of sirolimus from matrix tablets were observed. Results Based on the Results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC(K4M),2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class. Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.

ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
Citation: ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139.
shu

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