Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug
- Received Date: 2009-10-24
- Rev Recd Date: 2009-12-27
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Key words:
- sirolimus /
- matrix sustained-release tablets /
- drug release in vitro /
- HPMC
Abstract: Objective To prepare the sirolimus sustained-release tablets and study the influence factor. Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation Methods on the release of sirolimus from matrix tablets were observed. Results Based on the Results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC(K4M),2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class. Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.
Citation: | ZHANG Jing, WANG Juan, SONG Hong-tao, TANG Xing, HE Zhong-gui. Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 126-129,139. |