Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel
- Received Date: 2009-12-27
- Rev Recd Date: 2010-04-15
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Key words:
- tacrolimus(FK506) /
- thermosensitive ophthalmic gel /
- release in vitro /
- gel erosion /
- HPLC
Abstract: Objective To study the factors that influence the release of tacrolimus from the thermosensitive ophthalmic gel. Methods The non-membrane model was introduced to observe the influence on the drug release and gel erosion for surface area and shaking frequency. Results The drug release and gel erosion were increased with the rise of surface area and shaking frequency. Conclusion The drug release mainly depends on the gel erosion.
Citation: | ZHANG Jing, SONG Hong-tao, YANG Li-xia, ZHOU Xin. Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 267-270. |