Bioactive constituents from Sinularia sp
- Received Date: 2010-06-21
- Rev Recd Date: 2010-07-16
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Key words:
- Sinularia sp. /
- polyhydroxyled sterol /
- antimicrobial constituents
Abstract: Objective To study the bioactive constituents of soft coral Sinularia sp. Methods The compounds were isolated and purified by silica gel,Sephadex LH-20 column chromatography and HPLC.Their chemical structures were identified by spectroscopic analysis. Results Seven sterol compounds were identified that are: ergos-7,24(28)-dien-3β,5α,6β-triol(1),(24R)-ergost-7,22-dien-3β,5α,6β-triol(2),ergost-24(28)-en-3β,5α,6β-triol(3),(24 S)-ergost-7(8)-en-3β,5α,6β-triol(4),23-demethylgorgost-7-en-3β,5α,6β-triol(5),ergosterol peroxide(6),cholesterol(7). Conclusion s All these compounds have the ergost-3β,5α,6β-tiol substructure segment except the common ergosterol peroxide and cholesterol.Preliminary bioactive experiment indicated that these compounds have the effect of antimicrobial activity.
Citation: | MENG Li-yuan, LI Xiu-bao, ZHANG Wen, LI Ling, SUN Peng, TANG Hua, LIU Bao-shu, YI Yang-hua. Bioactive constituents from Sinularia sp[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 274-278. |