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LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
Citation: LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.

Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant

  • Received Date: 2010-03-25
  • Rev Recd Date: 2010-06-02
  • Objective To study the effect and mechanisms of timosaponin B-Ⅱ on depression. Methods The tail suspension test(TST),forced swimming test(FST),open field activity test(OFA),APO-induced synergistic action test,inhibiting reuptake of monoamine neurotransmitters and monoamine oxidase inhibitor(MAOI) test,yohimbine-induced lethality test and 5-HTP-induced head-twitch test were carried out to examine the antidepressant effect and mechanisms of timosaponin B-Ⅱ in rats.Immobility duration in FST and TST,spontaneous activity frequency in OFA,the stereotyped behaviors scores in APO-induced synergistic action test,and mortality in the other tests were observed. Results Timosaponin B-Ⅱ(100、150mg/kg) could effectively shorten the immobility time in TST and FST,but all dosages showed no significant effect on the spontaneous activity frequency in OFA.Timosaponin B-Ⅱ(150 mg/kg) significantly increased the rate of death of injecting dopamine,but had no obvious effect on the inhibiting reuptake of NE.Timosaponin B-Ⅱ(100、150 mg/kg) enhanced the apomorphine-induced stereotypy remarkably,which with statistically significant differences(P<0.05),and increased the head-twitch response evoked by 5-HTP,but had no effect on the yohimbine toxicity. Conclusion Timosaponin B-Ⅱhas significant antidepressant effect which may be related to the potentiation of brain 5-HT nerve system and DA nerve system.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant

Abstract: Objective To study the effect and mechanisms of timosaponin B-Ⅱ on depression. Methods The tail suspension test(TST),forced swimming test(FST),open field activity test(OFA),APO-induced synergistic action test,inhibiting reuptake of monoamine neurotransmitters and monoamine oxidase inhibitor(MAOI) test,yohimbine-induced lethality test and 5-HTP-induced head-twitch test were carried out to examine the antidepressant effect and mechanisms of timosaponin B-Ⅱ in rats.Immobility duration in FST and TST,spontaneous activity frequency in OFA,the stereotyped behaviors scores in APO-induced synergistic action test,and mortality in the other tests were observed. Results Timosaponin B-Ⅱ(100、150mg/kg) could effectively shorten the immobility time in TST and FST,but all dosages showed no significant effect on the spontaneous activity frequency in OFA.Timosaponin B-Ⅱ(150 mg/kg) significantly increased the rate of death of injecting dopamine,but had no obvious effect on the inhibiting reuptake of NE.Timosaponin B-Ⅱ(100、150 mg/kg) enhanced the apomorphine-induced stereotypy remarkably,which with statistically significant differences(P<0.05),and increased the head-twitch response evoked by 5-HTP,but had no effect on the yohimbine toxicity. Conclusion Timosaponin B-Ⅱhas significant antidepressant effect which may be related to the potentiation of brain 5-HT nerve system and DA nerve system.

LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
Citation: LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.

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