Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(4): 296-298,312

NING Wei-wei, LIU Xue-fei, ZHANG Xiao-meng, ZHENG Can-hui, SHENG Chun-quan, ZHOU You-jun, ZHANG Ling, LV Jia-guo, ZHU Ju. Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 296-298,312.
Citation: NING Wei-wei, LIU Xue-fei, ZHANG Xiao-meng, ZHENG Can-hui, SHENG Chun-quan, ZHOU You-jun, ZHANG Ling, LV Jia-guo, ZHU Ju. Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 296-298,312.
shu

Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor

  • Department of Medicinal Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2010-01-19
  • Rev Recd Date: 2010-03-09
  • Objective Novel 3-substituted quinazolinon compounds were designed and synthesised on the base of the active site of human acrosin. Methods The compounds were designed by computer and chemically synthesised. Results Seven 3-substituted quinazolinon compounds were designed and synthesised,subsequently carried out in vitro anti-acrosin test. Conclusion The Results of anti-acrosin tese in vitro exhibited that all the compounds showed potent anti-acrosin activities.Particularly,compounds 3 g displayed much stronger anti-acrosin activities(229 times) than that of TLCK.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2851) PDF downloads(465) Cited by()

Related
Proportional views

Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor

  • Department of Medicinal Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2010-01-19
  • Rev Recd Date: 2010-03-09

Abstract: Objective Novel 3-substituted quinazolinon compounds were designed and synthesised on the base of the active site of human acrosin. Methods The compounds were designed by computer and chemically synthesised. Results Seven 3-substituted quinazolinon compounds were designed and synthesised,subsequently carried out in vitro anti-acrosin test. Conclusion The Results of anti-acrosin tese in vitro exhibited that all the compounds showed potent anti-acrosin activities.Particularly,compounds 3 g displayed much stronger anti-acrosin activities(229 times) than that of TLCK.

NING Wei-wei, LIU Xue-fei, ZHANG Xiao-meng, ZHENG Can-hui, SHENG Chun-quan, ZHOU You-jun, ZHANG Ling, LV Jia-guo, ZHU Ju. Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 296-298,312.
Citation: NING Wei-wei, LIU Xue-fei, ZHANG Xiao-meng, ZHENG Can-hui, SHENG Chun-quan, ZHOU You-jun, ZHANG Ling, LV Jia-guo, ZHU Ju. Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 296-298,312.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return