Study on pharmacokinetics of compound Danshen dropping pills of new matrix
- Received Date: 2010-02-01
- Rev Recd Date: 2010-06-24
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Key words:
- new matrix /
- compound Danshen dropping pill /
- pharmacokinetics
Abstract: Objective To study the pharmacokinetics of compound Danshen dropping pills of new matrix. Methods HPLC was used as a detection method.New Zealand rabbits were taken as experimental animals.The compound Danshen dropping pills sold in market were taken as comparison products. Results There was a significant difference of Cmax and Ka between two kinds of pills(P<0.05).There was no significant different of tpeak、AUC、t1/2β,MRT and VRT.The relative bioavailability of compound Danshen dropping pills of new matrix was 114.5%. Conclusion The absorption rate constant and Cpeak of compound Danshen dropping pills of new matrix were much higher than the pills sold on the market.New matrix could improve the performance of quick Results and high efficiency of the dropping pills.The peak-time,the time of maintaining effective concentration and the elimination of drugs were same as old ones on the whole.
Citation: | Wang Wei, Wang Xiao-hua, Zhang Xiao-jie, Chen Jian-ming. Study on pharmacokinetics of compound Danshen dropping pills of new matrix[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 331-333. |