Development of nimodipine solid dispersion

Key words: 
• nimodipine /
• solid dispersion /
• dissolution

Abstract: Objective To prepare Nimodipine solid dispersion and increase its dissolution rate.Methonds Using polyvinylpyrrolidone(PVP) as a carrier,nimodipine solid dispersion was prepared by spray-drying method.differential scanning calorimetry and X-Ray powder Diffractometer were used to investigate the status of nimodipine in carriers,and dissolution characteristics were studied in vitro. Results Nimodipine was in the form of molecular in its carrier.The solubility of solid dispersion was significantly increased comparing with that of the pure drug or physical mixtures.Dissolution Results showed that higher carrier-Nimodipine ratio led to faster drug dissolution,t50 of solid dispersions(NimodipinePVP=1:3) is only 0.972 6 min. Conclusion Polyvinylpyrrolidone(PVP) as a carrier of Nimodipine solid dispersion has a high load ability;spray-drying method has good reproducibility;dispersoid particles need not to be smashed and can satisfy request for each kind of solid dosage form.Spray drying technique is a ideal method for the preparation of nimodipine solid dispersion.