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ZHAO Yu, JIANG Hua, XI Gui-lin, LI Hui-linag, YUAN Bo-jun, LU Guo-cai, ZHANG Wei-dong. Effects of Protoveratrine A on cardiovascular and respiratory system in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 348-351.
Citation: ZHAO Yu, JIANG Hua, XI Gui-lin, LI Hui-linag, YUAN Bo-jun, LU Guo-cai, ZHANG Wei-dong. Effects of Protoveratrine A on cardiovascular and respiratory system in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 348-351.

Effects of Protoveratrine A on cardiovascular and respiratory system in rats

  • Received Date: 2010-04-19
  • Rev Recd Date: 2010-06-02
  • Objective To observe the effects of Protoveratrine A(PA) on cardiovascular and respiratory system in rats. Methods The experimental rats(n=40,mf=1:1) were equally randomized into 4 groups: blank control group and groups of low dose(ig,0.25 mg/kg,single dose of PA),medium dose(ig,0.50 mg/kg,single dose of PA) and high dose(ig,1.00 mg/kg,single dose of PA).Carotid artery cannulation was established following anaesthesia in the rats and the effects of PA on the blood pressure,ECG,respiratory rate and width of rats were measured. Results The systolic blood pressure,diastolic blood pressure,mean arterial pressure,heart rate and respiratory rate of rats were decreased,the corrected QT(QTc) interval was prolonged and the respiratory width was increased in rats.The dose-effect relationships were observed for all the changes.However,these parameters returned to normal within 150 min. Conclusion PA has some effects on cardiovascular and respiratory systems in rats in reducing the blood pressure and heart rate,prolonging the QTc interval,decreasing the respiratory rate and increasing the respiratory width.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effects of Protoveratrine A on cardiovascular and respiratory system in rats

Abstract: Objective To observe the effects of Protoveratrine A(PA) on cardiovascular and respiratory system in rats. Methods The experimental rats(n=40,mf=1:1) were equally randomized into 4 groups: blank control group and groups of low dose(ig,0.25 mg/kg,single dose of PA),medium dose(ig,0.50 mg/kg,single dose of PA) and high dose(ig,1.00 mg/kg,single dose of PA).Carotid artery cannulation was established following anaesthesia in the rats and the effects of PA on the blood pressure,ECG,respiratory rate and width of rats were measured. Results The systolic blood pressure,diastolic blood pressure,mean arterial pressure,heart rate and respiratory rate of rats were decreased,the corrected QT(QTc) interval was prolonged and the respiratory width was increased in rats.The dose-effect relationships were observed for all the changes.However,these parameters returned to normal within 150 min. Conclusion PA has some effects on cardiovascular and respiratory systems in rats in reducing the blood pressure and heart rate,prolonging the QTc interval,decreasing the respiratory rate and increasing the respiratory width.

ZHAO Yu, JIANG Hua, XI Gui-lin, LI Hui-linag, YUAN Bo-jun, LU Guo-cai, ZHANG Wei-dong. Effects of Protoveratrine A on cardiovascular and respiratory system in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 348-351.
Citation: ZHAO Yu, JIANG Hua, XI Gui-lin, LI Hui-linag, YUAN Bo-jun, LU Guo-cai, ZHANG Wei-dong. Effects of Protoveratrine A on cardiovascular and respiratory system in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 348-351.

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