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Volume 28 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(5): 361-362

WANG Yan-qiong, ZHANG Shun-guo, Xu Tiao, CHEN Ming-lin, GUO Xiao-wen. Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 361-362.
Citation: WANG Yan-qiong, ZHANG Shun-guo, Xu Tiao, CHEN Ming-lin, GUO Xiao-wen. Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 361-362.
shu

Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags

  • 1.

    Department of Pharmacy,Shanghai Children's Medical Center affiliated to School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China

  • 2.

    School of Medicine,Jiao Tong University,Shanghai 200025,China

  • Received Date: 2010-05-05
  • Rev Recd Date: 2010-06-13
  • Objective To investigate chemical stability of cyclophosphamid in glass bottles and PVC infusion bags. Methods Cyclophosphamide was dissolved with 0.9% sodium chloride respectively in glass bottles and PVC bags.The storage condition for the solutions was room temperature.Solutions were sampled at 0,1,2,4,6,8,12 and 24 h,and the appearance and traits were observed.Cyclophosphamide concentrations were determined by HPLC. Results No obvious changes were founded in cyclophosphamide under different conditions.Two solutions were stable before 12h.The statistic Results had no significant difference(P>0.05). Conclusion Cyclophosphamide is stable in glass bottles and PVC bags in 0.9% sodium chloride injection.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags

  • 1. Department of Pharmacy,Shanghai Children's Medical Center affiliated to School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China
  • 2. School of Medicine,Jiao Tong University,Shanghai 200025,China
  • Received Date: 2010-05-05
  • Rev Recd Date: 2010-06-13

Abstract: Objective To investigate chemical stability of cyclophosphamid in glass bottles and PVC infusion bags. Methods Cyclophosphamide was dissolved with 0.9% sodium chloride respectively in glass bottles and PVC bags.The storage condition for the solutions was room temperature.Solutions were sampled at 0,1,2,4,6,8,12 and 24 h,and the appearance and traits were observed.Cyclophosphamide concentrations were determined by HPLC. Results No obvious changes were founded in cyclophosphamide under different conditions.Two solutions were stable before 12h.The statistic Results had no significant difference(P>0.05). Conclusion Cyclophosphamide is stable in glass bottles and PVC bags in 0.9% sodium chloride injection.

WANG Yan-qiong, ZHANG Shun-guo, Xu Tiao, CHEN Ming-lin, GUO Xiao-wen. Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 361-362.
Citation: WANG Yan-qiong, ZHANG Shun-guo, Xu Tiao, CHEN Ming-lin, GUO Xiao-wen. Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 361-362.
shu

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