Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags
- Received Date: 2010-05-05
- Rev Recd Date: 2010-06-13
-
Key words:
- HPLC /
- cyclophosphamide /
- stability /
Abstract: Objective To investigate chemical stability of cyclophosphamid in glass bottles and PVC infusion bags. Methods Cyclophosphamide was dissolved with 0.9% sodium chloride respectively in glass bottles and PVC bags.The storage condition for the solutions was room temperature.Solutions were sampled at 0,1,2,4,6,8,12 and 24 h,and the appearance and traits were observed.Cyclophosphamide concentrations were determined by HPLC. Results No obvious changes were founded in cyclophosphamide under different conditions.Two solutions were stable before 12h.The statistic Results had no significant difference(P>0.05). Conclusion Cyclophosphamide is stable in glass bottles and PVC bags in 0.9% sodium chloride injection.
Citation: | WANG Yan-qiong, ZHANG Shun-guo, Xu Tiao, CHEN Ming-lin, GUO Xiao-wen. Chemical stability of cyclophosphamide in glass bottle and PVC infusion bags[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 361-362. |