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Volume 28 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(5): 369-371,382

YANG Yang, GAO Yong-liang. Study on in vitro release and correlation between in vivo and in vivo of thienorphine hydrochloride microspheres[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 369-371,382.
Citation: YANG Yang, GAO Yong-liang. Study on in vitro release and correlation between in vivo and in vivo of thienorphine hydrochloride microspheres[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 369-371,382.
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Study on in vitro release and correlation between in vivo and in vivo of thienorphine hydrochloride microspheres

  • Institute of Pharrnacology and Toxicology,The Academy of Military Medical Sciences,Beijing 100850,China

  • Received Date: 2010-03-16
  • Rev Recd Date: 2010-05-10
  • Objective To establish a method for the determination of in vitro release of thienorphine hydrochloride micro-spheres with a good correlation between in vivo and in vitro. Methods Immediate release and dialysis release Methods were used to determine the in vitro release rate of thienorphine hydrochloride microspheres.The residue thienorphine hydrochloride microspheres in the injection site was determined by HPLC,and in vivo release rate of thienorphine hydrochloride microspheres was caculated.The optimal release solution was chosen based on the correlation evaluation between the in vivo and in vitro Results . Results Immediate release and dialysis release Methods had a good in vitro and in vivo correlation. Conclusion Immediate release and dialysis release method could be used to determine the in vitro release of thienorphine hydrochloride microspheres.
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Study on in vitro release and correlation between in vivo and in vivo of thienorphine hydrochloride microspheres

  • Institute of Pharrnacology and Toxicology,The Academy of Military Medical Sciences,Beijing 100850,China
  • Received Date: 2010-03-16
  • Rev Recd Date: 2010-05-10

Abstract: Objective To establish a method for the determination of in vitro release of thienorphine hydrochloride micro-spheres with a good correlation between in vivo and in vitro. Methods Immediate release and dialysis release Methods were used to determine the in vitro release rate of thienorphine hydrochloride microspheres.The residue thienorphine hydrochloride microspheres in the injection site was determined by HPLC,and in vivo release rate of thienorphine hydrochloride microspheres was caculated.The optimal release solution was chosen based on the correlation evaluation between the in vivo and in vitro Results . Results Immediate release and dialysis release Methods had a good in vitro and in vivo correlation. Conclusion Immediate release and dialysis release method could be used to determine the in vitro release of thienorphine hydrochloride microspheres.

YANG Yang, GAO Yong-liang. Study on in vitro release and correlation between in vivo and in vivo of thienorphine hydrochloride microspheres[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 369-371,382.
Citation: YANG Yang, GAO Yong-liang. Study on in vitro release and correlation between in vivo and in vivo of thienorphine hydrochloride microspheres[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 369-371,382.
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