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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(5): 372-373,395

JIN Feihong, CHEN Jie, YANG Wenchao. The efficacy and safety of diterpene ginkgolides meglumine injection in stroke: a Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 80-85. doi: 10.3969/j.issn.1006-0111.2019.01.019
Citation: XIE Hua, WANG Rong, JIA Zheng-ping, ZHANG Juan-hong. Content determination of carbamazepine tablet by liquid chromatographic tandem mass spectrometry[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 372-373,395.
shu

Content determination of carbamazepine tablet by liquid chromatographic tandem mass spectrometry

  • Base of Clinic Pharmacology,Lanzhou General Hospital,Lanzhou Command,Lanzhou 730050,China

  • Received Date: 2010-02-21
  • Rev Recd Date: 2010-04-25
  • Objective To develop liquid chromatography with tandem mass spectrometry(LC-MS/MS) detection for the content determination of carbamazepine tablet. Methods The method was used.The sample was analyzed on Zorbax Extend-C18(150 mm×4.6 mm,5 μm),with mobile phase consisting of methanol-0.01 mmol/l amine acetic acid(80:20,v/v) at a flow rate of 0.3 ml/min. Results It was proved to be linear in the range of 0.05～40 μg/ml with a regression coefficient of 0.999 4.The average recovery rate was 100.2%(n=5) and RSD was 1.02%.The RSD of average contents of intra-day and inter-day was 1.72% and 1.91% respectively.The concentrations of four lot samples were 96.3%,98.6%,96.5% and 99.0%,respectively. Conclusion This method is accurate,precise,sensitive and specific to be used in the content determination of carbamazepine tablet.
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Content determination of carbamazepine tablet by liquid chromatographic tandem mass spectrometry

  • Base of Clinic Pharmacology,Lanzhou General Hospital,Lanzhou Command,Lanzhou 730050,China
  • Received Date: 2010-02-21
  • Rev Recd Date: 2010-04-25

Abstract: Objective To develop liquid chromatography with tandem mass spectrometry(LC-MS/MS) detection for the content determination of carbamazepine tablet. Methods The method was used.The sample was analyzed on Zorbax Extend-C18(150 mm×4.6 mm,5 μm),with mobile phase consisting of methanol-0.01 mmol/l amine acetic acid(80:20,v/v) at a flow rate of 0.3 ml/min. Results It was proved to be linear in the range of 0.05～40 μg/ml with a regression coefficient of 0.999 4.The average recovery rate was 100.2%(n=5) and RSD was 1.02%.The RSD of average contents of intra-day and inter-day was 1.72% and 1.91% respectively.The concentrations of four lot samples were 96.3%,98.6%,96.5% and 99.0%,respectively. Conclusion This method is accurate,precise,sensitive and specific to be used in the content determination of carbamazepine tablet.

JIN Feihong, CHEN Jie, YANG Wenchao. The efficacy and safety of diterpene ginkgolides meglumine injection in stroke: a Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 80-85. doi: 10.3969/j.issn.1006-0111.2019.01.019
Citation: XIE Hua, WANG Rong, JIA Zheng-ping, ZHANG Juan-hong. Content determination of carbamazepine tablet by liquid chromatographic tandem mass spectrometry[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 372-373,395.
shu

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