Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids
- Received Date: 2010-04-28
- Rev Recd Date: 2010-05-14
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Key words:
- 4″-alkoxy-1,1′′,1″-terphenyl-4-carboxylic acid /
- synthesis /
- 4′-bromo-4-hydroxy-1,1′-biphenyl /
- Suzuki coupling
Abstract: Objective To prepare 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids(1),the key fatty acid chain which is pharmaceutical intermediates for the total synthesis of novel cyclohexalipopeptide antifungal agents such as Caspofungin analogs. Methods Starting from 4′-bromo-4-hydroxy-1,1′-biphenyl(2), Results target compounds 1a-1e were prepared via hydrocarbylation,halogen-mental exchange followed by condensation with triisopropyl borate and acid hydrolysis.
Citation: | LIU Hong-ming, QIN Ye, YAO Jian-zhong, SHENG Chun-quan, MIAO Zhen-yuan, ZHANG Wan-nian. Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 414-417,459. |