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LIU Hong-ming, QIN Ye, YAO Jian-zhong, SHENG Chun-quan, MIAO Zhen-yuan, ZHANG Wan-nian. Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 414-417,459.
Citation: LIU Hong-ming, QIN Ye, YAO Jian-zhong, SHENG Chun-quan, MIAO Zhen-yuan, ZHANG Wan-nian. Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 414-417,459.

Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids

  • Received Date: 2010-04-28
  • Rev Recd Date: 2010-05-14
  • Objective To prepare 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids(1),the key fatty acid chain which is pharmaceutical intermediates for the total synthesis of novel cyclohexalipopeptide antifungal agents such as Caspofungin analogs. Methods Starting from 4′-bromo-4-hydroxy-1,1′-biphenyl(2), Results target compounds 1a-1e were prepared via hydrocarbylation,halogen-mental exchange followed by condensation with triisopropyl borate and acid hydrolysis.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids

Abstract: Objective To prepare 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids(1),the key fatty acid chain which is pharmaceutical intermediates for the total synthesis of novel cyclohexalipopeptide antifungal agents such as Caspofungin analogs. Methods Starting from 4′-bromo-4-hydroxy-1,1′-biphenyl(2), Results target compounds 1a-1e were prepared via hydrocarbylation,halogen-mental exchange followed by condensation with triisopropyl borate and acid hydrolysis.

LIU Hong-ming, QIN Ye, YAO Jian-zhong, SHENG Chun-quan, MIAO Zhen-yuan, ZHANG Wan-nian. Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 414-417,459.
Citation: LIU Hong-ming, QIN Ye, YAO Jian-zhong, SHENG Chun-quan, MIAO Zhen-yuan, ZHANG Wan-nian. Synthesis of 4″-alkoxy-1,1′:4′,1″-terphenyl-4-carboxylic acids[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 414-417,459.

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