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Volume 28 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(6): 418-421,425

DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
Citation: DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
shu

Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion

  • 1.

    Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China;Department of Pharmacy,Shanghai Public Health Clinical Center,Shanghai 201508,China

  • 2.

    Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China

  • Received Date: 2010-03-30
  • Rev Recd Date: 2010-05-07
  • Objective To prepare Piroxicam microemulsion and investigate its transdermal characteristics in vitro. Methods The o/w microemulsion was prepared with the system contained of Lauroglycol FCC as oil phase,Labrasol and Cremophor EL as surfactants,Transcutol P and Ethanol as cosurfactants according to the pseudo-ternary phase diagrams.The transdermal characteristics were evaluated by modified Franz diffusion cell method.Rat's skin was used as permeation barrier and the drug concentration was measured by HPLC. Results The optimum formulation consisted of 0.5%Piroxicam,10%Lauroglycol FCC,50%water,13.3%Labrasol,Cremophor El and Transcutol P.The permeation rate of Piroxicam was 10.04±1.73 μg/(cm2·h). Conclusion The Results indicated that the optimum microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of Piroxicam.
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Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion

  • 1. Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China;Department of Pharmacy,Shanghai Public Health Clinical Center,Shanghai 201508,China
  • 2. Department of Pharmaceutics,school of Pharmacy,Fudan University,Shanghai 200032,China
  • Received Date: 2010-03-30
  • Rev Recd Date: 2010-05-07

Abstract: Objective To prepare Piroxicam microemulsion and investigate its transdermal characteristics in vitro. Methods The o/w microemulsion was prepared with the system contained of Lauroglycol FCC as oil phase,Labrasol and Cremophor EL as surfactants,Transcutol P and Ethanol as cosurfactants according to the pseudo-ternary phase diagrams.The transdermal characteristics were evaluated by modified Franz diffusion cell method.Rat's skin was used as permeation barrier and the drug concentration was measured by HPLC. Results The optimum formulation consisted of 0.5%Piroxicam,10%Lauroglycol FCC,50%water,13.3%Labrasol,Cremophor El and Transcutol P.The permeation rate of Piroxicam was 10.04±1.73 μg/(cm2·h). Conclusion The Results indicated that the optimum microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of Piroxicam.

DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
Citation: DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425.
shu

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