Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion
- Received Date: 2010-03-30
- Rev Recd Date: 2010-05-07
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Key words:
- piroxicam /
- microemulsion /
- transdermal permeation
Abstract: Objective To prepare Piroxicam microemulsion and investigate its transdermal characteristics in vitro. Methods The o/w microemulsion was prepared with the system contained of Lauroglycol FCC as oil phase,Labrasol and Cremophor EL as surfactants,Transcutol P and Ethanol as cosurfactants according to the pseudo-ternary phase diagrams.The transdermal characteristics were evaluated by modified Franz diffusion cell method.Rat's skin was used as permeation barrier and the drug concentration was measured by HPLC. Results The optimum formulation consisted of 0.5%Piroxicam,10%Lauroglycol FCC,50%water,13.3%Labrasol,Cremophor El and Transcutol P.The permeation rate of Piroxicam was 10.04±1.73 μg/(cm2·h). Conclusion The Results indicated that the optimum microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of Piroxicam.
Citation: | DONG Ping, WU Juan, SHA Xian-yi, FANG Xiao-ling. Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 418-421,425. |