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Volume 28 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(6): 448-450

XU Jun, CAI Rong, LU Wei-yi. The migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 448-450.
Citation: XU Jun, CAI Rong, LU Wei-yi. The migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 448-450.
shu

The migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium

  • Shanghai Food and Drug Packaging material Control Center,Shanghai 201203,China

  • Received Date: 2010-06-08
  • Rev Recd Date: 2010-09-14
  • Objective To study on the migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium. Methods GC method was used to detect the volatile substances from rubber stoppers and powders of ceftriaxone sodium for injection with clarity problems. Results The volatile substances from rubber stoppers with higher boiling point could be detected in the contacted ceftriaxone sodium samples while the volatile substances with lower boiling point and C13H23Br could not be detected in the samples. Conclusion The volatile substances with high boiling point originated from the rubber stoppers could migrate to ceftriaxone sodium powders and could be absorbed by the powders,and some transferred substances could even further react with ceftriaxone sodium.
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The migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium

  • Shanghai Food and Drug Packaging material Control Center,Shanghai 201203,China
  • Received Date: 2010-06-08
  • Rev Recd Date: 2010-09-14

Abstract: Objective To study on the migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium. Methods GC method was used to detect the volatile substances from rubber stoppers and powders of ceftriaxone sodium for injection with clarity problems. Results The volatile substances from rubber stoppers with higher boiling point could be detected in the contacted ceftriaxone sodium samples while the volatile substances with lower boiling point and C13H23Br could not be detected in the samples. Conclusion The volatile substances with high boiling point originated from the rubber stoppers could migrate to ceftriaxone sodium powders and could be absorbed by the powders,and some transferred substances could even further react with ceftriaxone sodium.

XU Jun, CAI Rong, LU Wei-yi. The migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 448-450.
Citation: XU Jun, CAI Rong, LU Wei-yi. The migration and possible influences of the volatile substances from rubber stoppers on ceftriaxone sodium[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 448-450.
shu

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