WANG Liang, NI Lan, ZHANG Chun-Mei, GUO Jun-Xiang, HU Hong-Gang, WU Qiu-Ye. Study on synthesis of Fmoc-L-Asp-4-OBn[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 27-28.
| Citation:
|
WANG Liang, NI Lan, ZHANG Chun-Mei, GUO Jun-Xiang, HU Hong-Gang, WU Qiu-Ye. Study on synthesis of Fmoc-L-Asp-4-OBn[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 27-28.
|
Study on synthesis of Fmoc-L-Asp-4-OBn
- 1.
School of Pharmacy, Yantai University, Yantai, 264005; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 2.
313th Hospital of PLA, Huludao 125000, China
- 3.
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2010-06-21
- Rev Recd Date:
2010-07-31
-
Abstract
Objective To design and synthetize new derivatives of aspartic acid from L-Asp-1-OtBu and to study the importance of new derivatives in the synthesis of cyclic peptide. Methods Starting from L-Asp-1-OtBu, the benzyl was introduced on the four position of the carbon, and then the tBu protecting was removed from the one position of the carbon to synthesis of the desired target compounds. Structures of these compounds were confirmed by MS, 1H-NMR.Results The Fmoc-L-Asp-4-OBn was synthetized with, yield of 61.3%. Conclusion The synthetic method is feasible, simple and with high yield for cyclic peptide synthesis.
-
References
|
[1]
|
印春生. 合成肽疫苗研究进展[J]. 中国兽药杂志, 2005, 39(11):29. |
|
[2]
|
易杨华, 李 玲, 林厚文, 等. 我国南海总合草苔虫和海绵中新的抗肿瘤活性成分的研究[J]. 第二军医大学学报,2002, 23 (3):236. |
|
[3]
|
Peletskaya EN, Glinsky VV, Glinsky GV, et al. Characterization of peptides that bind the tumor-associated homsen-friedenreich antigen selected from bacteriophage display libraries[J]. J Mol Biol, 1997, 270:374. |
|
[4]
|
Marshall GR. A Hierarchical Approach to Peptidomimetic Design[J]. Tetrahedron,1993, 49:3547. |
|
[5]
|
Bang JK, Hasegawa K, Kawakami T. Synthesis of an olefin-containing cyclic peptide using the solidphase horneremmons reaction[J]. Tetrahedron Letters,2004, 45:99. |
|
[6]
|
Gu W, Silverman, RB. Solid-Phase Total Synthesis of Scytalidamide A[J]. J Org Chem,2003, 68:8774. |
-
-
Proportional views
-
DownLoad: