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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(1): 35-37

LUO Ya, LIU Yan, HU Xi-xi, LU Feng. Fast detection of hypoglycemic drugs by portable Raman spectrometer[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 35-37.
Citation: LUO Ya, LIU Yan, HU Xi-xi, LU Feng. Fast detection of hypoglycemic drugs by portable Raman spectrometer[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 35-37.
shu

Fast detection of hypoglycemic drugs by portable Raman spectrometer

  • 1.

    The 169th hospital of PLA,Hengyang 421002,China

  • 2.

    School of Pharmaey Second Military Medical University, Shanghai 200433 ,China

  • Received Date: 2010-09-06
  • Rev Recd Date: 2010-12-08
  • Objective To investigate the identification capability of portable Raman spectrometer for hypoglycemic drugs. Methods The Raman spectra of the standard substance of active pharmaceutical ingredient of the hypoglycemic drugs and their corresponding preparations were obtained by the TruScan portable Raman spectrometer respectively, followed by the modified Local Straight-Line Screening (LSLS) treatment to decide whether the sample is counterfeited or not. Results Four kinds of hypoglycemic tablets and seven general pharmaceutical excipients were analyzed. The sensitivity, specificity and accuracy reach 100.00%, 94.44% and 96.36%, respectively. Conclusion Combined the portable Raman spectroscopy with the modified Local Straight-Line Screening algorithm, which was non-contact, non-destructive and could rapid analyze the counterfeit drugs on the spot.
  • [1] 陆 峰, 乐 健, 陈桂良, 等. 中药掺杂化学药物的分析及其对策[J]. 中国中药杂志, 2007, 32(1): 6.
    [2] 陈艳华, 陆 峰, 尹利辉, 等. 局部直线筛选法的建立及其改进研究[J]. 中国科学B辑, 2010, 40(8):1142.
    [3] 翁欣欣. 分子光谱学在食品与药品分析中的研究[D]. 第二军医大学硕士学位论文, 2010.
    [4] 刘可滇. 便携式拉曼光谱仪的设计[J]. 分析仪器, 2009, 4: 22.
    [5] 胡昌勤, 冯艳春, 薛 晶, 等. 药品快速检测系统的构想及研究进展[J]. 药物分析杂志, 2008, 28(4): 647.
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Fast detection of hypoglycemic drugs by portable Raman spectrometer

  • 1. The 169th hospital of PLA,Hengyang 421002,China
  • 2. School of Pharmaey Second Military Medical University, Shanghai 200433 ,China
  • Received Date: 2010-09-06
  • Rev Recd Date: 2010-12-08

Abstract: Objective To investigate the identification capability of portable Raman spectrometer for hypoglycemic drugs. Methods The Raman spectra of the standard substance of active pharmaceutical ingredient of the hypoglycemic drugs and their corresponding preparations were obtained by the TruScan portable Raman spectrometer respectively, followed by the modified Local Straight-Line Screening (LSLS) treatment to decide whether the sample is counterfeited or not. Results Four kinds of hypoglycemic tablets and seven general pharmaceutical excipients were analyzed. The sensitivity, specificity and accuracy reach 100.00%, 94.44% and 96.36%, respectively. Conclusion Combined the portable Raman spectroscopy with the modified Local Straight-Line Screening algorithm, which was non-contact, non-destructive and could rapid analyze the counterfeit drugs on the spot.

LUO Ya, LIU Yan, HU Xi-xi, LU Feng. Fast detection of hypoglycemic drugs by portable Raman spectrometer[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 35-37.
Citation: LUO Ya, LIU Yan, HU Xi-xi, LU Feng. Fast detection of hypoglycemic drugs by portable Raman spectrometer[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 35-37.
shu

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