Fast detection of hypoglycemic drugs by portable Raman spectrometer
- Received Date: 2010-09-06
- Rev Recd Date: 2010-12-08
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Key words:
- Raman spectroscopy /
- Local Straight-Line Screening /
- hypoglycemic drugs
Abstract: Objective To investigate the identification capability of portable Raman spectrometer for hypoglycemic drugs. Methods The Raman spectra of the standard substance of active pharmaceutical ingredient of the hypoglycemic drugs and their corresponding preparations were obtained by the TruScan portable Raman spectrometer respectively, followed by the modified Local Straight-Line Screening (LSLS) treatment to decide whether the sample is counterfeited or not. Results Four kinds of hypoglycemic tablets and seven general pharmaceutical excipients were analyzed. The sensitivity, specificity and accuracy reach 100.00%, 94.44% and 96.36%, respectively. Conclusion Combined the portable Raman spectroscopy with the modified Local Straight-Line Screening algorithm, which was non-contact, non-destructive and could rapid analyze the counterfeit drugs on the spot.
Citation: | LUO Ya, LIU Yan, HU Xi-xi, LU Feng. Fast detection of hypoglycemic drugs by portable Raman spectrometer[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 35-37. |