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Volume 29 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(2): 114-116

WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
Citation: WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
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Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design

  • School of Pharmacy, The Second Military Medical University, Shanghai 200433, China

  • Received Date: 2010-06-17
  • Rev Recd Date: 2010-11-01
  • Objective To optimize the synthesis of photosensitizer purpurin-18(1). Methods Target compound 1 was synthesized through air oxidation and simultaneously ring cleavage of pheophorbide a (2) in presence of alkali. Four main factors influencing synthetic yield of 1 such as reaction time (A), concentration of potassium hydroxide (B), solvent (C) and weight ratio of material 2 to potassium hydroxide (D),which was chosed three levels respectively,were evaluated by the orthogonal experimental design of L9 (34). Results The optimization term of the synthesis of target compound 1 was B1C2A2D2. The yield of 1 was raised from 34.4% to 45.6%. Conclusion The yield was raised. The reaction time was shortened and the toxic solvent was removed. The procedure was suitable for industrial production.
  • [1] 袁 媛,周传农.光动力治疗诱导肿瘤细胞凋亡的分子作用机制[J].中国激光医学杂志,1996, 5(2): 111.
    [2] 沈卫镝,姚建忠,方 勇,等. 叶绿素a降解产物紫红素-18的光动力效应[J].中国医药工业杂志,2001, 32(5): 217.
    [3] 姚建忠,许德余,陈文晖,等. 蚕沙叶绿素的降解及二氢卟吩P6酰胺衍生物的合成[J].中国医药工业杂志,1999, 30(9): 403.
    [4] 周怀梧. 医药用数理统计[M]. 济南:山东教育出版社,1986:148.
    [5] 张春华,严云良. 医药用数理统计[M]. 北京:科学出版社,2001:205.
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Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design

  • School of Pharmacy, The Second Military Medical University, Shanghai 200433, China
  • Received Date: 2010-06-17
  • Rev Recd Date: 2010-11-01

Abstract: Objective To optimize the synthesis of photosensitizer purpurin-18(1). Methods Target compound 1 was synthesized through air oxidation and simultaneously ring cleavage of pheophorbide a (2) in presence of alkali. Four main factors influencing synthetic yield of 1 such as reaction time (A), concentration of potassium hydroxide (B), solvent (C) and weight ratio of material 2 to potassium hydroxide (D),which was chosed three levels respectively,were evaluated by the orthogonal experimental design of L9 (34). Results The optimization term of the synthesis of target compound 1 was B1C2A2D2. The yield of 1 was raised from 34.4% to 45.6%. Conclusion The yield was raised. The reaction time was shortened and the toxic solvent was removed. The procedure was suitable for industrial production.

WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
Citation: WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
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