Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!
WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
Citation:
WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design
School of Pharmacy, The Second Military Medical University, Shanghai 200433, China
Received Date: 2010-06-17
Rev Recd Date:
2010-11-01
Abstract
Objective To optimize the synthesis of photosensitizer purpurin-18(1). Methods Target compound 1 was synthesized through air oxidation and simultaneously ring cleavage of pheophorbide a (2) in presence of alkali. Four main factors influencing synthetic yield of 1 such as reaction time (A), concentration of potassium hydroxide (B), solvent (C) and weight ratio of material 2 to potassium hydroxide (D),which was chosed three levels respectively,were evaluated by the orthogonal experimental design of L9 (34). Results The optimization term of the synthesis of target compound 1 was B1C2A2D2. The yield of 1 was raised from 34.4% to 45.6%. Conclusion The yield was raised. The reaction time was shortened and the toxic solvent was removed. The procedure was suitable for industrial production.
Abstract: Objective To optimize the synthesis of photosensitizer purpurin-18(1). Methods Target compound 1 was synthesized through air oxidation and simultaneously ring cleavage of pheophorbide a (2) in presence of alkali. Four main factors influencing synthetic yield of 1 such as reaction time (A), concentration of potassium hydroxide (B), solvent (C) and weight ratio of material 2 to potassium hydroxide (D),which was chosed three levels respectively,were evaluated by the orthogonal experimental design of L9 (34). Results The optimization term of the synthesis of target compound 1 was B1C2A2D2. The yield of 1 was raised from 34.4% to 45.6%. Conclusion The yield was raised. The reaction time was shortened and the toxic solvent was removed. The procedure was suitable for industrial production.
WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
Citation:
WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.
WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian. Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 114-116.