Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.
Citation: LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.

Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection

  • Received Date: 2010-04-19
  • Rev Recd Date: 2010-07-07
  • Objective To evaluate the efficacy and safety of cimetidine on Mycoplasma pneumoniae infection. Methonds 80 MPI patients were selected and randomized into the observation group and the control group averagely. The two groups were treated with azithromycin, while the observation group was given cimetidine additionally. Peripheral blood eosinophils (EOS) and total IgE (T-IgE) were detected before and after the treatment which were used to evaluated the effects of cimetidine. Results The cure rate of observation group was 60.00%s and significantly higher than that of the control group which was 37.50% There was statistically significant of the cure rate (P<0.05, see Table 1) between two groups. The EOS level of the observation group decreased significantly after a course of treatment (P<0.001, see Table 2), the EOS level of the control group also decreased but had no significant difference (P>0.05) with the level before treatment. T-IgE level of two groups nearly had no change. The observation group occurred 1case of rash and 1 case of gastrointestinal reaction. The control group occurred 3 cases of gastrointestinal reactions and 2 cases of rash. The adverse reaction rate of two groups had no significant difference (P>0.05). Conclusion Cimetidine for adjuvant treatment of MPI with azithromycin is efficiency and safety which should be recommended in clinic.
  • [1] 李 军,崔其亮,张费通. 布地奈德悬液辅助治疗儿童肺炎支原体感染的疗效[J]. 实用医学杂志,2009,25(15):2550.
    [2] 王立凤.小儿支原体肺炎314例临床分析[J].中国临床医生杂志,2008,36(3):43.
    [3] 胡亚美,江载芳.诸福棠实用儿科学[M].7版.北京:人民卫生出版社,2002.
    [4] 何宗明. 西米替丁佐治小儿肺炎支原体感染72例临床分析[J]. 国际医药卫生导报,2010,16(02):208.
    [5] Yanagihara K, Izumikawa K, Higa F,et al. Efficacy of azithromycin in the treatment of community-acquired pneumonia, including patients with macrolide-resistant Streptococcus pneumoniae infection[J]. Intern Med,2009,48(7):527.
    [6] Morozum IM,Hasegawa K,Chiba N,et al.Application of PCR for Mycoplasm a pneumoniae detection in children with communitvacquired pneumonia[J].Infect Chem other,2004,10(5):274.
    [7] 肖选华.西米替丁在儿科临床的新用途[J].医学理论与实践,2004,17(3):281.
    [8] 张可林.西米替丁治疗FAPA综合症(周期性发热伴口、咽、颈淋巴结炎综合症)[J].国外医学儿科分册,1992,19(5):279.
    [9] 汤 光.现代药物学[M].北京:中国科技医药出版社,1996:508.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2316) PDF downloads(193) Cited by()

Related
Proportional views

Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection

Abstract: Objective To evaluate the efficacy and safety of cimetidine on Mycoplasma pneumoniae infection. Methonds 80 MPI patients were selected and randomized into the observation group and the control group averagely. The two groups were treated with azithromycin, while the observation group was given cimetidine additionally. Peripheral blood eosinophils (EOS) and total IgE (T-IgE) were detected before and after the treatment which were used to evaluated the effects of cimetidine. Results The cure rate of observation group was 60.00%s and significantly higher than that of the control group which was 37.50% There was statistically significant of the cure rate (P<0.05, see Table 1) between two groups. The EOS level of the observation group decreased significantly after a course of treatment (P<0.001, see Table 2), the EOS level of the control group also decreased but had no significant difference (P>0.05) with the level before treatment. T-IgE level of two groups nearly had no change. The observation group occurred 1case of rash and 1 case of gastrointestinal reaction. The control group occurred 3 cases of gastrointestinal reactions and 2 cases of rash. The adverse reaction rate of two groups had no significant difference (P>0.05). Conclusion Cimetidine for adjuvant treatment of MPI with azithromycin is efficiency and safety which should be recommended in clinic.

LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.
Citation: LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.
Reference (9)

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return